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浅针刺治疗慢性颈部疼痛:一项采用功能磁共振成像和扩散张量成像的多中心随机对照试验方案

Shallow Acupuncture for Chronic Neck Pain: A Multicenter Randomized Controlled Trial Protocol with fMRI and DTI.

作者信息

Lin Jiahui, Gu Zhilin, Zhou Peng, Huang Weikang, Ou Aihua, Zhao Qi, Xu Zhenhua

机构信息

The second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.

Department of Acupuncture, Shenzhen Bao'an Traditional Chinese Medicine Hospital, Shenzhen, People's Republic of China.

出版信息

J Pain Res. 2025 Apr 11;18:1963-1973. doi: 10.2147/JPR.S512989. eCollection 2025.


DOI:10.2147/JPR.S512989
PMID:40236722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11998947/
Abstract

PURPOSE: This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), an innovative approach not commonly applied in shallow acupuncture research. PATIENTS AND METHODS: This multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants will be randomly assigned to three groups: shallow acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 patients per group. The primary outcomes include total effective rate, visual analogue scale (VAS), Neck Disability Index (NDI), and brain imaging results (20 randomly selected patients per group). Secondary outcomes include the Self-Rating Anxiety Scale (SAS), Short Form 36 Questionnaire (SF-36), and cervical range of motion (CROM). Data will be collected at baseline, after 2 weeks, and at 3-month follow-up. fMRI and DTI data will be collected at baseline and after 2 weeks. Analyses will include regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), fractional anisotropy (FA), and mean diffusivity (MD) within and between groups. An additional 20 healthy volunteers will provide baseline fMRI and DTI data for comparison. CONCLUSION: This study will validate the clinical efficacy of shallow acupuncture for CNP and explore its central mechanisms using fMRI and DTI. The findings may provide neuroimaging evidence supporting the broader clinical application of shallow acupuncture in treating CNS-related diseases.

摘要

目的:本研究旨在利用功能磁共振成像(fMRI)和扩散张量成像(DTI)探索浅针治疗慢性颈部疼痛(CNP)的中枢机制,这是一种在浅针研究中不常用的创新方法。 患者与方法:这项多中心随机对照试验将从三个中心招募252名CNP患者(每个中心84名)。参与者将被随机分为三组:浅针组、药物对照组(塞来昔布胶囊)或等待列表组,每组84名患者。主要结局包括总有效率、视觉模拟量表(VAS)、颈部功能障碍指数(NDI)和脑成像结果(每组随机选取20名患者)。次要结局包括自评焦虑量表(SAS)、简短健康调查量表(SF-36)和颈椎活动度(CROM)。数据将在基线、2周后和3个月随访时收集。fMRI和DTI数据将在基线和2周后收集。分析将包括组内和组间的局部一致性(ReHo)、低频振幅(ALFF)、功能连接(FC)、分数各向异性(FA)和平均扩散率(MD)。另外20名健康志愿者将提供基线fMRI和DTI数据用于比较。 结论:本研究将验证浅针治疗CNP的临床疗效,并利用fMRI和DTI探索其中枢机制。研究结果可能为浅针在治疗中枢神经系统相关疾病中的更广泛临床应用提供神经影像学证据。

相似文献

[1]
Shallow Acupuncture for Chronic Neck Pain: A Multicenter Randomized Controlled Trial Protocol with fMRI and DTI.

J Pain Res. 2025-4-11

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Local abnormal white matter microstructure in the spinothalamic tract in people with chronic neck and shoulder pain.

Front Neurosci. 2025-1-6

[2]
Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.

Front Neurosci. 2024-6-14

[3]
Global, regional, and national burden of neck pain, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.

Lancet Rheumatol. 2024-3

[4]
Investigating the brain functional abnormalities underlying pain hypervigilance in chronic neck and shoulder pain: a resting-state fMRI study.

Neuroradiology. 2024-8

[5]
The influence of exercise on pain, disability and quality of life in office workers with chronic neck pain: A systematic review and meta-analysis.

Appl Ergon. 2024-5

[6]
Modulatory effects of acupuncture on raphe nucleus-related brain circuits in patients with chronic neck pain: A randomized neuroimaging trial.

CNS Neurosci Ther. 2024-3

[7]
Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons.

Brain. 2023-10-3

[8]
Clinical efficacy of the shallow puncture and more-twirling acupuncture method in migraine treatment and its effects on serum 5-HT and β-EP levels.

Technol Health Care. 2023

[9]
Central sensitization, chronic pain, and other symptoms: Better understanding, better management.

Cleve Clin J Med. 2023-4-3

[10]
Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients.

CNS Neurosci Ther. 2023-7

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