BAT (Investments) Limited, Regents Park Road, Millbrook, Southampton, SO15 8TL, UK.
Intern Emerg Med. 2023 Aug;18(5):1359-1371. doi: 10.1007/s11739-023-03294-9. Epub 2023 May 30.
Electronic cigarette (EC) aerosol emissions generally contain fewer and lower concentrations of harmful and potentially harmful constituents, compared with cigarette smoke. Further studies are needed to establish whether decreased emissions translate to reduced health risks for EC users. In a cross-sectional study, biomarkers of exposure (BoE) to certain tobacco smoke toxicants and biomarkers of potential harm (BoPH), associated with biological processes linked to the potential development of smoking-related diseases and oxidative stress, were assessed in solus Vuse ECs users and current, former, and never smokers. In total, 213 participants were enrolled, and smoking status was confirmed by urinary cotinine, exhaled carbon monoxide, and N-(2-cyanoethyl)valine levels (EC users and former smokers only). During confinement participants used their usual product (EC or cigarette) as normal and BoE and BoPHs were assessed via blood, 24-h urine, and physiological assessment. Significantly lower levels of all urinary BoE; MHBMA, HMPMA, 3-HPMA, NNN, 3-OH-B[a]P, S-PMA, NNAL (all p < 0.0001), and TNeq (p = 0.0074) were observed in EC users when compared with smokers. Moreover, significantly lower levels were observed in EC users for 3 of the 7 BoPH measured, carboxyhaemoglobin (p < 0.0001), soluble intercellular adhesion molecule-1 (p = 0.0028), and 11-dehydrothromboxane B2 (p = 0.0012), when compared with smokers. As compared with smokers, solus Vuse EC users have significantly lower exposure to tobacco toxicants for the BoE, and 3 BoPH measured. These results add to the weight of evidence supporting EC as part of a tobacco harm reduction strategy.
电子烟（EC）气溶胶的排放物通常比香烟含有更少和更低浓度的有害和潜在有害成分。需要进一步的研究来确定排放量的减少是否转化为 EC 用户健康风险的降低。在一项横断面研究中，评估了使用 Solus Vuse EC 的人群以及当前、曾经和从不吸烟者体内接触某些烟草烟雾毒素的生物标志物（BoE）和潜在危害生物标志物（BoPH），这些标志物与与吸烟相关疾病和氧化应激潜在发展相关的生物过程有关。总共有 213 名参与者被纳入研究，通过尿液可替宁、呼出一氧化碳和 N-（2-氰乙基）缬氨酸水平（仅 EC 用户和前吸烟者）确认吸烟状态。在限制期间，参与者使用他们通常使用的产品（EC 或香烟），并通过血液、24 小时尿液和生理评估来评估 BoE 和 BoPH。与吸烟者相比，EC 用户的所有尿液 BoE 水平均显著降低（所有 p<0.0001），包括 MHBMA、HMPMA、3-HPMA、NNN、3-OH-B[a]P、S-PMA、NNAL 和 TNeq。此外，在 7 个测量的 BoPH 中，有 3 个 BoPH 的水平在 EC 用户中也显著降低，包括羧基血红蛋白（p<0.0001）、可溶性细胞间黏附分子-1（p=0.0028）和 11-脱氢血栓烷 B2（p=0.0012）。与吸烟者相比，Solus Vuse EC 用户的 BoE 和 3 个 BoPH 测量的烟草毒素暴露水平显著降低。这些结果进一步证明了 EC 作为减少烟草危害策略的一部分。
