McEwan Michael, Gale Nathan, Ebajemito James K, Camacho Oscar M, Hardie George, Proctor Christopher J, Murphy James
British American Tobacco (Investments) Limited, Research and Development, Regents Park Road, Southampton, SO15 8TL, UK.
DoctorProctorScience Ltd., 157 Cavendish Meads, Sunninghill, Ascot, SL5 9TG, UK.
Toxicol Rep. 2021 May 8;8:994-1001. doi: 10.1016/j.toxrep.2021.05.003. eCollection 2021.
Cigarette smoking is associated with a number of diseases, such as cancer and cardiovascular diseases. Recently, there has been an increase in the use of electronic cigarettes (ECs) and tobacco-heating products (THPs) as an alternative to cigarettes, which may reduce the health burden associated with smoking. However, an exposure continuum when smokers switch to ECs or THPs compared to complete smoking cessation is not well established.
148 healthy smokers were randomized to either continue smoking cigarettes, switch to using the glo THP or a prototype EC, or completely quit any nicotine or tobacco product use for 5 days, after a 2-day baseline period. During this study breath and 24-h urine samples were collected for Biomarker of Exposure (BoE) analysis.
After a 5-day switching period BoE levels showed a substantial significant decrease in levels from baseline in the groups using the glo THP, the prototype EC, and having quit all nicotine and tobacco use. On an exposure continuum, smokers who completely quit nicotine had the lowest levels of assessed BoEs, followed by those who switched to the EC and then those who switched to glo THP use. Participants who continued to smoke had the highest levels of BoEs.
THP or EC use over a 5-day period resulted in significant reductions in exposure to smoke toxicants, in some cases to levels similar to those for nicotine cessation. These results show that on an exposure continuum, nicotine cessation gives the greatest reduction in exposure to tobacco smoke toxicants, closely followed by the EC and the glo THP. These significant reductions in exposure to toxicants suggest that the glo THP and EC have the potential to be Reduced Risk Products.
ISRCTN80651909.
吸烟与多种疾病相关，如癌症和心血管疾病。最近，电子烟（EC）和烟草加热产品（THP）作为香烟的替代品，其使用有所增加，这可能会减轻与吸烟相关的健康负担。然而，与完全戒烟相比，吸烟者转向使用电子烟或烟草加热产品时的暴露连续体尚未明确确立。
148名健康吸烟者在经过2天的基线期后，被随机分为继续吸烟、转而使用glo烟草加热产品或一种原型电子烟，或完全停止使用任何尼古丁或烟草产品5天。在这项研究中，收集了呼吸样本和24小时尿液样本用于暴露生物标志物（BoE）分析。
在为期5天的转换期后，使用glo烟草加热产品组、原型电子烟组以及已停止所有尼古丁和烟草使用组的BoE水平相较于基线水平均出现大幅显著下降。在暴露连续体上，完全戒掉尼古丁的吸烟者的评估BoE水平最低，其次是转向使用电子烟的吸烟者，然后是转向使用glo烟草加热产品的吸烟者。继续吸烟的参与者的BoE水平最高。
在5天内使用烟草加热产品或电子烟导致烟雾毒物暴露显著减少，在某些情况下，暴露水平与戒烟者相似。这些结果表明，在暴露连续体上，戒烟能最大程度减少烟草烟雾毒物暴露，其次是电子烟和glo烟草加热产品。毒物暴露的显著减少表明glo烟草加热产品和电子烟有可能成为风险降低产品。
ISRCTN80651909。
