Cheng Jue, Cheng Lin, Kong Ling-Wei, Qiu Wenfeng, Zhuang Runtao
Jue Cheng, Department of Stomatology, Beijing Jiaotong University Hospital, Beijing 100000, Beijing, China.
Lin Cheng, Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences), Taiyuan 030000, Shanxi, China.
Pak J Med Sci. 2023 May-Jun;39(3):710-714. doi: 10.12669/pjms.39.3.6899.
To investigate and analyze the clinical observation of porcine collagen membrane + artificial bovine bone granules guided tissue regeneration (GTR) combined with autologous concentration of growth factors (CGF) in the treatment of severe periodontitis bone defect.
A total of 94 patients with severe periodontitis bone defects admitted to Shanxi Bethune Hospital from January 2019 to January 2022 were included. They were divided into two groups by simple randomization method. Patients in the control group were treated with porcine collagen membrane + artificial bovine bone granules GTR, while those in the observation group were treated with autologous CGF on the basis of the control group. Before and after treatment, periodontal clinical indicators [sulcus bleeding index (SBI), gingival retreat index (GR), probing depth (PD), clinical attachment loss (CAL), alveolar bone height (AH)] and bone resorption markers [Osteoprotegerin (OPG), bone gla protein (BGP), Type-1 collagen N-terminal peptide (NTX)] were compared between the two groups, and the incidence of postoperative complications in the two groups was recorded.
The total efficacy of observation group was significantly higher than that of control group (0.05). Three months after surgery, the observation group had lower levels of SBI, PD, CAL and NTX while higher levels of GR, AH, OPG and BGP than the control group (0.05). There was no significant difference in complication rate between the two groups (0.05).
Porcine collagen membrane + artificial bovine bone granules GTR combined with autologous CGF boasts various benefits in the treatment of severe periodontitis bone defects, such as improvement of clinical outcomes, amelioration of periodontal tissue and inhibition of bone resorption.
探讨并分析猪胶原膜+人工骨牛骨颗粒引导组织再生（GTR）联合自体浓缩生长因子（CGF）治疗重度牙周炎骨缺损的临床观察。
纳入2019年1月至2022年1月在山西白求恩医院收治的94例重度牙周炎骨缺损患者。采用简单随机化方法将其分为两组。对照组患者采用猪胶原膜+人工骨牛骨颗粒GTR治疗，观察组患者在对照组基础上加用自体CGF治疗。比较两组治疗前后的牙周临床指标[龈沟出血指数（SBI）、牙龈退缩指数（GR）、探诊深度（PD）、临床附着丧失（CAL）、牙槽骨高度（AH）]和骨吸收标志物[骨保护素（OPG）、骨钙素（BGP）、Ⅰ型胶原N端肽（NTX）]，并记录两组术后并发症的发生率。
观察组总有效率显著高于对照组（P<0.05）。术后3个月，观察组的SBI、PD、CAL和NTX水平低于对照组，而GR、AH、OPG和BGP水平高于对照组（P<0.05）。两组并发症发生率比较，差异无统计学意义（P>0.05）。
猪胶原膜+人工骨牛骨颗粒GTR联合自体CGF治疗重度牙周炎骨缺损具有诸多益处，如改善临床疗效、改善牙周组织及抑制骨吸收等。
