Wu Liqin, Xu Haili, Shen Guodong, Qin Li, Ma Lijie, Shen Wenxia
Department of Stomatology, Tongxiang Hospital of Traditional Chinese Medicine, Tongxiang City, Zhejiang, China.
Saudi J Anaesth. 2025 Jul-Sep;19(3):309-317. doi: 10.4103/sja.sja_606_24. Epub 2025 Jun 16.
Periodontal bone defects pose a significant challenge in stomatology, affecting dental stability and function.
This study aimed to explore the clinical efficacy of concentrated growth factor (CGF) combined with artificial or autologous bone powder in the treatment of periodontal bone defects.
A total of 106 patients with bone defects requiring surgical intervention were divided into two groups: the control group and the observation group. Preoperative data were analyzed, and postoperative periodontal indicators, bone resorption markers, and masticatory function were assessed at baseline and 2 weeks, 1 month, 3 months, and 6 months post surgery.
There were no significant differences in baseline characteristics between the two groups. The observation group showed improvements in periodontal probing depth, mucosal recession, plaque index, gingival index, gingival retreat index, and bone gla protein after 6 months. The masticatory function of the observation group was significantly better at 1 to 6 months post operation, and there were significant differences in postoperative pain levels at 6 months.
CGF combined with artificial bone powder demonstrates superior performance in masticatory function recovery and periodontal clinical parameter restoration, indicating potential benefits for periodontal bone defect treatment.
牙周骨缺损在口腔医学中构成重大挑战，影响牙齿稳定性和功能。
本研究旨在探讨浓缩生长因子（CGF）联合人工骨粉或自体骨粉治疗牙周骨缺损的临床疗效。
将106例需要手术干预的骨缺损患者分为两组：对照组和观察组。分析术前数据，并在基线以及术后2周、1个月、3个月和6个月评估牙周指标、骨吸收标志物和咀嚼功能。
两组基线特征无显著差异。观察组在6个月后牙周探诊深度、黏膜退缩、菌斑指数、牙龈指数、牙龈退缩指数和骨钙素有所改善。观察组术后1至6个月咀嚼功能明显更好，6个月时术后疼痛水平存在显著差异。
CGF联合人工骨粉在咀嚼功能恢复和牙周临床参数恢复方面表现出卓越性能，表明对牙周骨缺损治疗有潜在益处。
