Meyer Oanh L, Park Van Ta, Kanaya Alka M, Farias Sarah Tomaszewski, Hinton Ladson, Tiet Quyen Q, Vuong Quyen, Nguyen Stephanie, Harvey Danielle, Whitmer Rachel A
School of Medicine University of California, Davis Sacramento California USA.
University of California, San Francisco San Francisco California USA.
Alzheimers Dement (N Y). 2023 May 24;9(2):e12392. doi: 10.1002/trc2.12392. eCollection 2023 Apr-Jun.
There is a dearth of research on cognitive aging and dementia in Asian Americans, particularly Vietnamese Americans, who are the fourth largest Asian subgroup in the United States. The National Institutes of Health is mandated to make certain that racially and ethnically diverse populations are included in clinical research. Despite the widespread recognition to ensure that research findings can be generalizable to all groups, there are no estimates of the prevalence or incidence of mild cognitive impairment and Alzheimer's disease and related dementias (ADRD) in Vietnamese Americans, nor do we understand ADRD risk and protective factors in this group. In this article, we posit that studying Vietnamese Americans contributes to a better understanding of ADRD in general and offers unique opportunities for elucidating life course and sociocultural factors that contribute to cognitive aging disparities. That is, the unique context of Vietnamese Americans may provide understanding in terms of within-group heterogeneity and key factors in ADRD and cognitive aging. Here, we provide a brief history of Vietnamese American immigration and describe the large but often ignored heterogeneity of Asian Americans in the United States, elucidate how early life adversity and stress might influence late-life cognitive aging, and provide a basis for the role of sociocultural and health factors in the study of Vietnamese cognitive aging disparities. Research with older Vietnamese Americans provides a unique and timely opportunity to more fully delineate the factors that contribute to ADRD disparities for all populations.
针对亚裔美国人,尤其是越南裔美国人(美国第四大亚裔群体)的认知衰老和痴呆症的研究十分匮乏。美国国立卫生研究院被授权确保临床研究纳入不同种族和族裔的人群。尽管人们普遍认识到要确保研究结果能够推广到所有群体,但目前尚无关于越南裔美国人中轻度认知障碍、阿尔茨海默病及相关痴呆症(ADRD)的患病率或发病率的估计,我们也不了解该群体中ADRD的风险和保护因素。在本文中,我们认为对越南裔美国人的研究有助于更全面地理解ADRD,并为阐明导致认知衰老差异的生命历程和社会文化因素提供独特机会。也就是说,越南裔美国人的独特背景可能有助于从群体内部异质性以及ADRD和认知衰老的关键因素方面提供理解。在此,我们简要介绍越南裔美国人的移民历史,描述在美国常被忽视的亚裔美国人的巨大异质性,阐明早年的逆境和压力可能如何影响晚年的认知衰老,并为社会文化和健康因素在越南裔认知衰老差异研究中的作用提供依据。对年长越南裔美国人的研究为更全面地描绘导致所有人群ADRD差异的因素提供了独特且及时的机会。