Li Jing, Yan Peirao, Li Yong, Han Ming, Zeng Qi, Li Juan, Yu Zhe, Zhang Dongjie, Chen Xueli
Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, Shaanxi, China.
Center for Biomedical-photonics and Molecular Imaging, Xi'an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
Front Chem. 2023 May 12;11:1211121. doi: 10.3389/fchem.2023.1211121. eCollection 2023.
Eye diseases can cause great inconvenience to people's daily life; therefore, it is necessary to study the causes of ocular diseases and related physiological processes. Raman spectroscopic imaging (RSI) is a non-destructive, non-contact detection technique with the advantages of label-free, non-invasive and highly specific. Compared with other mature imaging technologies, RSI can provide real-time molecular information and high-resolution imaging at relatively low cost, making it very suitable for quantitative detection of biological molecules. RSI can reflect the overall situation of the sample, revealing the content distribution of the same substance in different areas of the sample. This review focuses on the recent advances in ophthalmology, with particular emphasis on the powerful use of RSI techniques, as well as its combination with other imaging techniques. Finally, we prospect the wider application and future potential of RSI approaches in ophthalmology.
眼部疾病会给人们的日常生活带来极大不便；因此，研究眼部疾病的病因及相关生理过程很有必要。拉曼光谱成像（RSI）是一种无损、非接触式检测技术，具有无需标记、非侵入性和高特异性等优点。与其他成熟的成像技术相比，RSI能够以相对较低的成本提供实时分子信息和高分辨率成像，使其非常适合生物分子的定量检测。RSI可以反映样品的整体情况，揭示同一物质在样品不同区域的含量分布。本综述聚焦于眼科领域的最新进展，特别强调RSI技术的强大应用，以及它与其他成像技术的结合。最后，我们展望了RSI方法在眼科领域更广泛的应用和未来潜力。
