Sadek I A
Oncology. 1986;43(4):268-70. doi: 10.1159/000226379.
Egyptian toads, Bufo regularis, were fed with cholic acid (sodium salt) 3 times/week for 12 weeks at different dose levels (2.5, 5, and 10 mg/toad). Results obtained showed only 1 case in both the 5 and 10 mg/toad doses that gave a tumor. Toads receiving N-methyl-N-nitrosourea (MNU) 1 mg/toad, 3 times/week for 12 weeks had 36% ileum tumors (18 toads out of 50, without mortality). On the other hand, a higher dose of MNU (5 mg/toad) caused 50% mortality in the experimental animals. Toads treated with MNU at a dose level of 1 mg/toad were subjected to CA at dose levels of 2.5, 5, 10 mg/toad. They showed a 48, 66 and 76% higher incidence of ileum tumors at the three different dose levels, respectively. It is concluded that cholic acid has a promoting effect on ileum tumor evoked by MNU in toads as in mammals.
给埃及蟾蜍（Bufo regularis）每周3次喂食胆酸（钠盐），持续12周，剂量分别为2.5、5和10毫克/蟾蜍。结果显示，5毫克/蟾蜍和10毫克/蟾蜍剂量组各只有1例出现肿瘤。每周3次给蟾蜍注射1毫克/蟾蜍的N-甲基-N-亚硝基脲（MNU），持续12周，回肠肿瘤发生率为36%（50只中有18只，无死亡）。另一方面，较高剂量的MNU（5毫克/蟾蜍）导致实验动物50%死亡。用1毫克/蟾蜍剂量的MNU处理的蟾蜍，再分别用2.5、5、10毫克/蟾蜍剂量的胆酸处理。在这三个不同剂量水平下，回肠肿瘤发生率分别高出48%、66%和76%。结论是，胆酸对蟾蜍中由MNU诱发的回肠肿瘤有促进作用，这与在哺乳动物中的情况相同。
