College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130012, P. R. China.
Adv Healthc Mater. 2023 Oct;12(27):e2301066. doi: 10.1002/adhm.202301066. Epub 2023 Jun 7.
DNA origami technology, a unique type of DNA nanotechnology, has attracted much attention from researchers and is applied in various fields. Through exquisite design and precise self-assembly of four kinds of deoxyribonucleotides, DNA origami nanostructures are endowed with excellent programmability and addressability and show outstanding biocompatibility in bio-related applications, especially in cancer treatment. In this review, nanomaterials based on DNA origami for cancer therapy are concluded, whereby chemotherapy and photo-assisted therapy are the main focus. Furthermore, the working mechanisms of the functional materials attached to the rigid DNA structures to enable targeted delivery and circumvent drug resistance are also discussed. DNA origami nanostructures are valuable carriers for delivering multifunctional therapeutic agents and demonstrate great potential in cancer treatment both in vitro and in vivo. It is undoubted that DNA origami technology is a promising strategy for constructing versatile nanodevices in biological fields and will excel in human healthcare.
DNA 折纸技术是一种独特的 DNA 纳米技术，引起了研究人员的广泛关注，并应用于各个领域。通过对四种脱氧核苷酸的精巧设计和精确自组装，DNA 折纸纳米结构具有优异的可编程性和可寻址性，在生物相关应用中表现出出色的生物相容性，特别是在癌症治疗方面。本综述总结了用于癌症治疗的基于 DNA 折纸的纳米材料，其中化疗和光辅助治疗是主要关注点。此外，还讨论了附着在刚性 DNA 结构上的功能材料的工作机制，以实现靶向递送和规避耐药性。DNA 折纸纳米结构是递送多功能治疗剂的有价值载体，在体外和体内的癌症治疗中都具有巨大的潜力。毫无疑问，DNA 折纸技术是构建生物领域多功能纳米器件的一种很有前途的策略，将在人类医疗保健中大放异彩。
