Zhang Yiming, Tian Xinchen, Wang Zijian, Wang Haochen, Liu Fen, Long Qipeng, Jiang Shulong
Clinical Medical Laboratory Center, Jining First People's Hospital, Shandong First Medical University, Jining, Shandong, China.
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Front Mol Biosci. 2023 Aug 7;10:1239952. doi: 10.3389/fmolb.2023.1239952. eCollection 2023.
DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands and creates specific structures based on the complementary base pairing principle. These innovative DNA origami nanostructures provide numerous benefits, including lower biotoxicity, increased stability, and superior adaptability, making them an excellent choice for transporting anti-tumor agents. Furthermore, they can considerably reduce side effects and improve therapy success by offering precise, targeted, and multifunctional drug delivery system. This comprehensive review looks into the principles and design strategies of DNA origami, providing valuable insights into this technology's latest research achievements and development trends in the field of anti-tumor drug delivery. Additionally, we review the key function and major benefits of DNA origami in cancer treatment, some of these approaches also involve aspects related to DNA tetrahedra, aiming to provide novel ideas and effective solutions to address drug delivery challenges in cancer therapy.
DNA折纸术是一种前沿的DNA自组装技术，它能巧妙地折叠DNA链，并根据碱基互补配对原则创建特定结构。这些创新的DNA折纸纳米结构具有诸多优点，包括较低的生物毒性、更高的稳定性和卓越的适应性，使其成为运输抗肿瘤药物的理想选择。此外，它们可以通过提供精确、靶向和多功能的药物递送系统，大大减少副作用并提高治疗成功率。这篇综述探讨了DNA折纸术的原理和设计策略，为该技术在抗肿瘤药物递送领域的最新研究成果和发展趋势提供了有价值的见解。此外，我们还综述了DNA折纸术在癌症治疗中的关键功能和主要优点，其中一些方法还涉及与DNA四面体相关的方面，旨在为解决癌症治疗中的药物递送挑战提供新思路和有效解决方案。
