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[对肺母细胞瘤发生敏感和抗性小鼠呼吸道原基器官培养的形态发生和生长潜能]

[Morphogenesis and growth potentials of organ cultures of the respiratory tract anlage of mice susceptible and resistant to pulmonary blastomogenesis].

作者信息

Kolesnichenko T S, Medvinskiĭ A L

出版信息

Ontogenez. 1986 May-Jun;17(3):293-302.

PMID:3725294
Abstract

The morphogenesis and growth potencies have been studied in the long-term organ cultures of different parts of the respiratory tract early rudiment in the mouse strains susceptible (A) and resistant (C57BL) against lung blastomogenesis. Similarities and peculiarities have been shown for the lung rudiment cells developing in vitro and in vivo. The linear differences have been established in morphogenesis and growth potencies of the proximal and distal parts of the respiratory tract rudiment. Possible importance of phenotypic differences in realization of the genetically determined sensitivity of the mouse-lung tissue to spontaneous and induced blastomogenesis is discussed.

摘要

在对易患(A品系)和抗患(C57BL品系)肺母细胞瘤形成的小鼠品系呼吸道早期原基不同部位进行的长期器官培养中,研究了形态发生和生长潜能。已显示出体外和体内发育的肺原基细胞的异同。已确定呼吸道原基近端和远端部分在形态发生和生长潜能方面的线性差异。讨论了表型差异在实现小鼠肺组织对自发和诱导性肿瘤发生的遗传决定敏感性中的可能重要性。

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