College of Life Sciences, North China University of Science and Technology, Tangshan, 063210, Hebei, China.
College of Grassland Science and Technology, China Agricultural University, Beijing, 100193, China.
BMC Genomics. 2023 May 30;24(1):290. doi: 10.1186/s12864-023-09389-z.
In the evolutionary study of gene families, exploring the duplication mechanisms of gene families helps researchers understand their evolutionary history. The tubby-like protein (TLP) family is essential for growth and development in plants and animals. Much research has been done on its function; however, limited information is available with regard to the evolution of the TLP gene family. Herein, we systematically investigated the evolution of TLP genes in seven representative Poaceae lineages.
Our research showed that the evolution of TLP genes was influenced not only by whole-genome duplication (WGD) and dispersed duplication (DSD) but also by transposed duplication (TRD), which has been neglected in previous research. For TLP family size, we found an evolutionary pattern of progressive shrinking in the grass family. Furthermore, the evolution of the TLP gene family was at least affected by evolutionary driving forces such as duplication, purifying selection, and base mutations.
This study presents the first comprehensive evolutionary analysis of the TLP gene family in grasses. We demonstrated that the TLP gene family is also influenced by a transposed duplication mechanism. Several new insights into the evolution of the TLP gene family are presented. This work provides a good reference for studying gene evolution and the origin of duplication.
在基因家族的进化研究中，探索基因家族的复制机制有助于研究人员了解其进化历史。管状蛋白（TLP）家族对动植物的生长和发育至关重要。其功能已经进行了大量研究，但关于 TLP 基因家族的进化信息有限。在此，我们系统地研究了七个代表性禾本科植物谱系中 TLP 基因的进化。
我们的研究表明，TLP 基因的进化不仅受到全基因组复制（WGD）和分散复制（DSD）的影响，还受到转座复制（TRD）的影响，而这在以前的研究中被忽视了。对于 TLP 家族的大小，我们发现禾本科植物家族呈现出逐渐缩小的进化模式。此外，TLP 基因家族的进化至少受到复制、纯化选择和碱基突变等进化驱动力的影响。
本研究首次对禾本科植物中的 TLP 基因家族进行了全面的进化分析。我们证明 TLP 基因家族也受到转座复制机制的影响。本研究提出了关于 TLP 基因家族进化的一些新见解。这项工作为研究基因进化和复制起源提供了很好的参考。
