青蒿琥酯通过核因子κB信号通路对气道MUC5AC黏蛋白基因表达的调控，青蒿琥酯是一种抗疟药。
Regulation of the Gene Expression of Airway MUC5AC Mucin through NF-κB Signaling Pathway by Artesunate, an Antimalarial Agent.
作者信息
Kim Kyung-Il, Hossain Rajib, Ryu Jiho, Lee Hyun Jae, Lee Choong Jae
机构信息
Department of Pharmacology, School of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Brain Korea 21 FOUR Project for Medical Science, Chungnam National University, Daejeon 35015, Republic of Korea.
出版信息
Biomol Ther (Seoul). 2023 Sep 1;31(5):544-549. doi: 10.4062/biomolther.2023.048. Epub 2023 May 31.
In this study, artesunate, an antimalarial agent, was investigated for its potential effect on the gene expression of airway MUC5AC mucin. The human pulmonary epithelial NCI-H292 cells were pretreated with artesunate for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA), for the following 24 h. The effect of artesunate on PMA-induced nuclear factor kappa B (NF-kB) signaling pathway was also examined. Artesunate inhibited the glycoprotein production and mRNA expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa Bα (IkBα) and NF-kB p65 nuclear translocation. These results suggest artesunate suppresses the gene expression of mucin through regulation of NF-kB signaling pathway, in human pulmonary epithelial cells.
在本研究中，对青蒿琥酯（一种抗疟药）对气道MUC5AC粘蛋白基因表达的潜在影响进行了研究。人肺上皮NCI-H292细胞先用青蒿琥酯预处理30分钟，然后用佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA）刺激24小时。还检测了青蒿琥酯对PMA诱导的核因子κB（NF-κB）信号通路的影响。青蒿琥酯通过抑制抑制性κBα（IkBα）的降解和NF-κB p65核转位，抑制了PMA诱导的MUC5AC粘蛋白的糖蛋白产生和mRNA表达。这些结果表明，在人肺上皮细胞中，青蒿琥酯通过调节NF-κB信号通路抑制粘蛋白的基因表达。
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