加拿大艾伯塔省埃德蒙顿梅毒致死胎病例系列。
Case Series of Stillbirths Due to Syphilis in Edmonton, Alberta, Canada.
机构信息
From the Department of Pediatrics, University of Alberta.
Sexually Transmitted Infections Services, Provincial, Population, and Public Health, Alberta Health Services, Edmonton, Alberta, Canada.
出版信息
Sex Transm Dis. 2023 Sep 1;50(9):591-594. doi: 10.1097/OLQ.0000000000001838. Epub 2023 May 28.
BACKGROUND
Data on the incidence and characteristics of stillbirths attributed to congenital syphilis were collected.
METHODS
We extracted data on stillbirths in the Edmonton Zone on January 1, 2015, through June 30, 2021, born to persons diagnosed with infectious syphilis (primary, secondary, early latent, or early neurosyphilis) during pregnancy or at the time of delivery.
RESULTS
Of 314 infants documented to be exposed to infectious syphilis during gestation, 16 (5.1%) were stillborn. Three of the 16 females with stillbirths were diagnosed with syphilis during pregnancy but not treated, 12 were diagnosed only at the time of stillbirth (1 of whom was treated early in pregnancy and presumably reinfected), and 1 had a stillbirth in the week after one dose of benzathine penicillin G.
CONCLUSIONS
Stillbirths due to congenital syphilis were all due to failure to treat syphilis in pregnancy. Innovative strategies to prevent syphilis in the community and to reach those experiencing barriers to care are urgently required to not miss opportunities to diagnose and treat syphilis as early as possible during pregnancy.
背景
收集了归因于先天性梅毒的死产发生率和特征的数据。
方法
我们提取了 2015 年 1 月 1 日至 2021 年 6 月 30 日期间，在埃德蒙顿地区因妊娠期间或分娩时诊断患有感染性梅毒（原发性、二期、早期潜伏性或早期神经梅毒）的人所生的死产儿的数据。
结果
在有记录的 314 名暴露于妊娠期间感染性梅毒的婴儿中，有 16 名（5.1%）为死产。在 16 名患有死产的女性中，有 3 名在妊娠期间被诊断患有梅毒但未接受治疗，12 名仅在死产时被诊断（其中 1 名在妊娠早期接受了治疗，可能再次感染），1 名在单次苄星青霉素 G 治疗后一周内死产。
结论
由于先天性梅毒导致的死产均归因于妊娠期间梅毒未得到治疗。需要创新的策略来预防社区中的梅毒，并为那些面临护理障碍的人提供服务，以避免错过在妊娠期间尽早诊断和治疗梅毒的机会。
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