Yin Mengchuang, Tang Shengchang, Li Caijie, Qin Zhipeng, You Hui
School of Mechanical Engineering, Guangxi University, Guangxi Provincial, Nanning, 530004, China.
Anal Sci. 2023 Oct;39(10):1777-1787. doi: 10.1007/s44211-023-00378-6. Epub 2023 May 31.
In this study, the innovative design of a new array microdroplet parallel-generation device is proposed based on the principle of fluid inertial force using a capillary glass needle. The entire device used an electromagnetic actuator as the power source. It was designed as a 9-channel parallel array of glass needles. All glass needles feed independently, allowing different solutions to be sprayed simultaneously while effectively avoiding cross-contamination. We achieved non-contact parallel precision dispensing of nanoliter-sized microdroplet arrays using a relatively simple method. In this study, we first investigated the homogeneity of the generated droplet arrays and the stability of the device over long periods of operation. Then, the influence of the driving-voltage amplitude of the electromagnet and nozzle diameter on microdroplet generation was analyzed. Finally, a prediction model for the droplet size was developed using regression analysis to investigate the on-demand generation of droplets. In summary, the device designed in this study had a novel design, low cost, and modular assembly. It has excellent potential for applications in high precision and low-volume microdroplet-array generation.
在本研究中,基于流体惯性力原理,利用毛细管玻璃针提出了一种新型阵列微滴并行生成装置的创新设计。整个装置使用电磁致动器作为动力源。它被设计成一个9通道玻璃针并行阵列。所有玻璃针独立进料,允许同时喷射不同溶液,同时有效避免交叉污染。我们使用相对简单的方法实现了纳升尺寸微滴阵列的非接触式并行精确分配。在本研究中,我们首先研究了生成的微滴阵列的均匀性以及装置在长时间运行中的稳定性。然后,分析了电磁铁驱动电压幅值和喷嘴直径对微滴生成的影响。最后,利用回归分析建立了液滴尺寸预测模型,以研究液滴的按需生成。总之,本研究设计的装置设计新颖、成本低且组件模块化。它在高精度、小体积微滴阵列生成方面具有出色的应用潜力。