Gaston Benjamin, Gardner Donna D, Mahan Kenzie, Akuthota Praveen, Mendonca Eneida A, Durrington Hannah, Marozkina Nadzeya, Martinez-Nunez Rocio T, Newcomb Dawn, Ainsworth Benjamin, Owora Arthur H, Chung Kian Fan, Walker Samantha, Fowler Stephen J, Siddiqui Salman, Winders Tonya, Zein Joe, Jarjour Nizar, Huang Yvonne J, Cahill Katherine N, Djukanovic Ratko
Indiana University, Indianapolis, IN, USA.
Allergy and Asthma Network, Fairfax, VA, USA.
ERJ Open Res. 2023 May 30;9(3). doi: 10.1183/23120541.00090-2023. eCollection 2023 May.
Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on type 2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 and immunity. An international group of investigators developed the International Collaborative Asthma Network (ICAN) with the goal of sharing innovative research on disease mechanisms, developing new technologies and therapies, organising pilot studies and engaging early-stage career investigators from across the world. This report describes the purpose, development and outcomes of the first ICAN forum.
Abstracts were solicited from interdisciplinary early-stage career investigators with innovative ideas beyond T2 inflammation for asthma and were selected for presentation at the forum. Breakout sessions were conducted to discuss innovation, collaboration and research translation.
The abstracts were categorised into: 1) general omics and big data analysis; 2) lung-brain axis and airway neurology; 3) sex differences; 4) paediatric asthma; 5) new therapeutic targets inspired by airway epithelial biology; 6) new therapeutics targeting airway and circulating immune mediators; and 7) lung anatomy, physiology and imaging. Discussions revealed that research groups are looking for opportunities to further their findings using larger scale collaboration and the ability to translate their findings into clinical treatment.
Through ICAN, teams that included interdisciplinary early-stage career investigators discussed innovation, collaboration and translation in asthma and severe asthma research. With a combination of fresh ideas and energetic, collaborative, global participation, ICAN has laid a firm foundation and model for future collaborative global asthma research.
尽管有可用的治疗方法，但许多患者的哮喘仍未得到有效控制。大多数新的哮喘治疗方法都集中在2型（T2）炎症上，对于T2和免疫之外的哮喘机制的创新性研究仍存在未满足的需求。一个国际研究团队成立了国际协作哮喘网络（ICAN），其目标是分享关于疾病机制的创新性研究、开发新技术和疗法、组织试点研究并吸引来自世界各地的早期职业研究人员参与。本报告描述了首届ICAN论坛的目的、发展情况和成果。
向具有超越哮喘T2炎症创新性想法的跨学科早期职业研究人员征集摘要，并挑选出在论坛上进行展示。组织了分组会议来讨论创新、合作和研究转化。
摘要被分为以下几类：1）一般组学和大数据分析；2）肺-脑轴与气道神经学；3）性别差异；4）儿童哮喘；5）受气道上皮生物学启发的新治疗靶点；6）针对气道和循环免疫介质的新疗法；7）肺解剖学、生理学和影像学。讨论表明，研究团队正在寻找机会，通过更大规模的合作进一步推进他们的研究结果，并将其研究结果转化为临床治疗方法。
通过ICAN，包括跨学科早期职业研究人员的团队讨论了哮喘和重度哮喘研究中的创新、合作和转化。凭借新颖的想法以及积极、协作的全球参与，ICAN为未来全球哮喘合作研究奠定了坚实的基础并树立了典范。
