Roshanzadeh Ghazal, Jahanian Sadatmahalleh Shahideh, Moini Ashraf, Mottaghi Azadeh, Rostami Farahnaz
Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Reprod Biomed. 2023 May 8;21(4):333-342. doi: 10.18502/ijrm.v21i4.13272. eCollection 2023 May.
Fewer studies were on micronutrient intake in women with endometriosis, and the etiology of endometriosis remains unclear between dietary micronutrients and the risk of endometriosis.
This study aimed to investigate the relationship between dietary micronutrients and the risk of endometriosis.
This case-control study was conducted on 156 women (18-45 yr) with and without endometriosis in the gynecology clinic of Arash hospital between May 2017 and May 2018 in Tehran, Iran. According to the laparoscopic findings, the participants were divided into 2 groups (n = 78/each), women with pelvic endometriosis as the case group and women without endometriosis pelvic as the control group. Dietary data were collected using a validated 168-item semiquantitative food frequency questionnaire with the standard serving. A logistic regression model was used to determine the association between micronutrients and the risk of endometriosis.
Data analysis showed a significant relationship between micronutrients such as: potassium (OR: 0.74; CI: 0.56-0.99; p = 0.01), calcium (OR: 0.70; CI: 0.52-0.94; p = 0.003), and also among the vitamin C (OR: 0.70; CI: 0.52-0.94; p = 0.02), B2 (OR: 0.73; CI: 0.55-0.98; p = 0.01), and B12 (OR: 0.71; CI: 0.53-0.95; p = 0.02) with endometriosis, so those who used fewer micronutrients were at higher risk of endometriosis.
The findings showed that the dietary intakes of calcium, potassium, vitamins B12, B2, B6, and C are inversely related to the risk of endometriosis.
关于子宫内膜异位症女性的微量营养素摄入情况的研究较少，饮食中的微量营养素与子宫内膜异位症风险之间的病因关系仍不清楚。
本研究旨在调查饮食微量营养素与子宫内膜异位症风险之间的关系。
本病例对照研究于2017年5月至2018年5月在伊朗德黑兰的阿拉什医院妇科诊所对156名年龄在18至45岁之间患有和未患有子宫内膜异位症的女性进行。根据腹腔镜检查结果，将参与者分为两组（每组n = 78），患有盆腔子宫内膜异位症的女性作为病例组，未患有盆腔子宫内膜异位症的女性作为对照组。使用经过验证的包含168个项目的半定量食物频率问卷收集饮食数据，并采用标准份量。采用逻辑回归模型来确定微量营养素与子宫内膜异位症风险之间的关联。
数据分析显示，钾（比值比：0.74；可信区间：0.56 - 0.99；p = 0.01）、钙（比值比：0.70；可信区间：0.52 - 0.94；p = 0.003）等微量营养素，以及维生素C（比值比：0.70；可信区间：0.52 - 0.94；p = 0.02）、维生素B2（比值比：0.73；可信区间：0.55 - 0.98；p = 0.01）和维生素B12（比值比：0.71；可信区间：0.53 - 0.95；p = 0.02）与子宫内膜异位症之间存在显著关系，因此微量营养素摄入量较少的人患子宫内膜异位症的风险更高。
研究结果表明，钙、钾、维生素B12、B2、B6和C的饮食摄入量与子宫内膜异位症风险呈负相关。
