Etemadi Leila, Enander Jonas M D, Jörntell Henrik
Neural Basis of Sensorimotor Control, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
iScience. 2023 May 13;26(6):106885. doi: 10.1016/j.isci.2023.106885. eCollection 2023 Jun 16.
Due to continuous state variations in neocortical circuits, individual somatosensory cortex (SI) neurons display a variety of intracellular responses to the exact same spatiotemporal tactile input pattern. To manipulate the internal cortical state, we here used brief electrical stimulation of the output region of the hippocampus, which preceded the delivery of specific tactile afferent input patterns to digit 2 of the anesthetized rat. We find that hippocampal output had a diversified, remarkably strong impact on the intracellular response types displayed by each neuron in the primary SI to each given tactile input pattern. Qualitatively, this impact was comparable to that previously described for cortical output, which was surprising given the widely assumed specific roles of the hippocampus, such as in cortical memory formation. The findings show that hippocampal output can profoundly impact the state-dependent interpretation of tactile inputs and hence influence perception, potentially with affective and semantic components.
由于新皮质回路中持续的状态变化，个体体感皮层（SI）神经元对完全相同的时空触觉输入模式会表现出多种细胞内反应。为了操纵内部皮质状态，我们在此对海马体输出区域进行短暂电刺激，该刺激先于向麻醉大鼠的第二指递送特定的触觉传入输入模式。我们发现，海马体输出对初级体感皮层中每个神经元对每种给定触觉输入模式所显示的细胞内反应类型具有多样化且非常强烈的影响。定性地说，这种影响与先前描述的皮质输出的影响相当，鉴于人们普遍认为海马体具有特定作用，如在皮质记忆形成中，这一结果令人惊讶。这些发现表明，海马体输出可深刻影响触觉输入的状态依赖性解释，从而影响感知，可能还涉及情感和语义成分。
