Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, Yinchuan, China.
J Drug Target. 2023 Dec;31(10):1050-1064. doi: 10.1080/1061186X.2023.2283829. Epub 2023 Nov 29.
Therapy on lipid metabolism is emerging as a groundbreaking cancer treatment, offering the unprecedented opportunity to effectively treat and in several cases. Tumorigenesis is inextricably linked to lipid metabolism. In this regard, the features of lipid metabolism include lipid synthesis, decomposition, metabolism and lipid storage and mobilisation from intracellular lipid droplets. Most importantly, the regulation of lipid metabolism is central to the appropriate immune response of tumour cells, and ultimately to exert the immune efforts to realise the perspective of many anti-tumour effects. Different cancers and immune cells have different dependence on lipid metabolism, playing a pivotal role in differentiation and function of immune cells. However, what lies before the immunotherapy targeting lipid metabolism is side effects of systemic toxicity and defects of individual drugs, which strongly highlights that nanodelivery strategy is a magnet for it to enhance drug efficiency, reduce drug toxicity and improve application deficiencies. This review will first focus on emerging research progress of lipid metabolic reprogramming mechanism, and then explore the complex role of lipid metabolism in the tumour cells including the effect on immune cells and their nano-preparations of monotherapy and multiple therapies used in combination, in a shift away from conventional cancer research.HighlightsThe regulation of lipid metabolism is central to the appropriate immune response of tumour cells, and ultimately to exert the immune efforts to realise the perspective of many anti-tumour effects.Preparations of focusing lipid metabolism have side effects of systemic toxicity and defects of individual drugs. It strongly highlights that nanodelivery strategy is a magnet for it to enhance drug efficiency, reduce drug toxicity and improve application deficiencies.This review will first focus on emerging research progress of lipid metabolic reprogramming mechanism, and then explore the complex role of lipid metabolism in the tumour cells including the effect on immune cells as well as their nano-preparations of monotherapy and multiple therapies used in combination, in a shift away from conventional cancer research.
脂质代谢治疗正成为一种突破性的癌症治疗方法，为有效治疗癌症提供了前所未有的机会，在某些情况下甚至可以治愈癌症。肿瘤发生与脂质代谢密切相关。在这方面，脂质代谢的特征包括脂质合成、分解、代谢以及细胞内脂滴中的脂质储存和动员。最重要的是，脂质代谢的调节是肿瘤细胞适当免疫反应的核心，最终发挥免疫作用，实现许多抗肿瘤效果的前景。不同的癌症和免疫细胞对脂质代谢的依赖程度不同，在免疫细胞的分化和功能中起着关键作用。然而，针对脂质代谢的免疫疗法面临着全身毒性副作用和个别药物缺陷的问题，这强烈凸显了纳米递药策略是提高药物效率、降低药物毒性和改善应用缺陷的关键。本综述首先将重点介绍脂质代谢重编程机制的最新研究进展，然后探讨脂质代谢在肿瘤细胞中的复杂作用，包括对免疫细胞的影响及其在单一和联合治疗中的纳米制剂，从而摆脱传统的癌症研究。
亮点：
脂质代谢的调节是肿瘤细胞适当免疫反应的核心，最终发挥免疫作用，实现许多抗肿瘤效果的前景。
聚焦脂质代谢的制剂存在全身毒性副作用和个别药物缺陷的问题。这强烈凸显了纳米递药策略是提高药物效率、降低药物毒性和改善应用缺陷的关键。
本综述首先将重点介绍脂质代谢重编程机制的最新研究进展，然后探讨脂质代谢在肿瘤细胞中的复杂作用，包括对免疫细胞的影响及其在单一和联合治疗中的纳米制剂，从而摆脱传统的癌症研究。
