College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, PR China; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, PR China.
Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119506. doi: 10.1016/j.bbamcr.2023.119506. Epub 2023 May 31.
Alternative pre-mRNA splicing, which produces various mRNA isoforms with distinct structures and functions from a single gene, is regulated by specific RNA-binding proteins and is an essential method for regulating gene expression in mammals. Recent studies have shown that abnormal change during neuronal development triggered by splicing mis-regulation is an important feature of various neurological diseases. Polypyrimidine tract binding protein 1 (PTBP1) is a kind of RNA-binding proteins with extensive biological functions. As a well-known splicing regulator, it affects the neuronal development process through its involvement in axon formation, synaptogenesis, and neuronal apoptosis, according to the most recent studies. Here, we summarized the mechanism of alternative splicing, structure and function of PTBP1, and the latest research progress on the role of alternative splicing events regulated by PTBP1 in axon formation, synaptogenesis and neuronal apoptosis, to reveal the mechanism of PTBP1-regulated changes in neuronal development process.
选择性剪接，即从单个基因产生具有不同结构和功能的多种 mRNA 异构体，受特定的 RNA 结合蛋白调控，是哺乳动物中调节基因表达的一种重要方法。最近的研究表明，神经元发育过程中剪接调控异常改变是各种神经疾病的一个重要特征。多嘧啶 tract 结合蛋白 1（PTBP1）是一种具有广泛生物学功能的 RNA 结合蛋白。作为一种众所周知的剪接调控因子，根据最近的研究，它通过参与轴突形成、突触发生和神经元凋亡来影响神经元发育过程。在这里，我们总结了选择性剪接的机制、PTBP1 的结构和功能，以及由 PTBP1 调控的选择性剪接事件在轴突形成、突触发生和神经元凋亡中的作用的最新研究进展，以揭示 PTBP1 调节的神经元发育过程变化的机制。
