螺旋藻补充剂对血脂谱的影响：基于随机对照试验数据的 GRADE 评估系统评价和剂量反应荟萃分析。
The effect of Spirulina supplementation on lipid profile: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials.
机构信息
Department of Health and Nutrition, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
出版信息
Pharmacol Res. 2023 Jul;193:106802. doi: 10.1016/j.phrs.2023.106802. Epub 2023 May 30.
BACKGROUND
Cardiovascular diseases (CVD) are one of the most important causes of death worldwide. Dyslipidemia is one of the main causal risk factors for CVD that can be controlled by modifying lifestyle, which entails the use of healthy diets containing functional foods. The present study was conducted to summarize the effects of Spirulina on the lipid profile in previous randomized controlled trials.
METHODS
MEDLINE, Scopus, Clarivate Analytics Web of Science, and the Cochrane Library databases were searched systematically until January 2023, for clinical interventions that investigated the effect of Spirulina supplementation on plasma lipid profile concentrations.
RESULTS
ooled results of 20 studies (with 23 arms and 1076 participants) indicated that Spirulina intervention significantly reduced LDL-C (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05), TC (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05) and TG (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05) levels while HDL-C levels were significantly increased (SMD: 0.3, 95% CI: 0.0, 0.6, P<0.05).
CONCLUSIONS
The findings of the present meta-analysis and review show the usefulness of supplementing with Spirulina in improving serum levels of TC, TG, LDL-C, and HDL-C.
背景
心血管疾病 (CVD) 是全球最重要的死亡原因之一。血脂异常是 CVD 的主要因果风险因素之一，可以通过改变生活方式来控制，这需要使用含有功能性食品的健康饮食。本研究旨在总结先前随机对照试验中螺旋藻对血脂谱的影响。
方法
系统检索 MEDLINE、Scopus、科睿唯安 Web of Science 和 Cochrane 图书馆数据库，直至 2023 年 1 月，以调查螺旋藻补充剂对血浆脂质谱浓度影响的临床干预措施。
结果
20 项研究（23 个臂和 1076 名参与者）的汇总结果表明，螺旋藻干预可显著降低 LDL-C（SMD：-0.6，95%CI：-0.9，-0.2，P<0.05）、TC（SMD：-0.6，95%CI：-0.9，-0.2，P<0.05）和 TG（SMD：-0.6，95%CI：-0.9，-0.2，P<0.05）水平，而 HDL-C 水平则显著升高（SMD：0.3，95%CI：0.0，0.6，P<0.05）。
结论
本荟萃分析和综述的研究结果表明，补充螺旋藻在改善 TC、TG、LDL-C 和 HDL-C 血清水平方面具有一定的作用。
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