Zhang Xiaolei, Miao Jinxin, Song Yagang, Miao Mingsan
Academy of Chinese Medical Sciences Henan University of Chinese Medicine Zhengzhou China.
Henan Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao Henan University of Chinese Medicine Zhengzhou China.
Food Sci Nutr. 2024 Nov 20;12(12):10049-10058. doi: 10.1002/fsn3.4599. eCollection 2024 Dec.
The clinical research findings on the effects of okra consumption on blood glucose and lipids are inconsistent. In this study, we aimed to explore the impact of okra consumption on glycemic parameters and lipid profile in adults, including homeostatic model assessment for insulin resistance (HOMA-IR), glycosylated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). To find relevant randomized controlled trials (RCTs), we systemically searched EMBASE, Web of Science, PubMed, Cochrane Library, and Scopus until April 2024. According to the inclusion and exclusion criteria, eight studies involving 521 participants were ultimately included in the present study. Compared to placebo, okra consumption remarkably decreased FBG (WMD: -32.56 mg/dL; 95% CI: -48.83, -16.28; < 0.001; = 84.7%), HbA1c (WMD: -0.48%; 95% CI: -0.81, -0.16; = 0.004; = 5.5%), TG (WMD: -13.16 mg/dL; 95% CI: -23.54, -2.77; = 0.013; = 0.0%), and TC (WMD: -9.70 mg/dL; 95% CI: -14.95, -4.46; < 0.001; = 38.3%) in adults. However, okra showed no notable impact on HOMA-IR, HDL-C, and LDL-C. Okra consumption has an improving effect on adult FBG, HbA1c, TG, and TC levels. More large-scale RCT studies are necessary to validate the beneficial effects of okra on adults due to the limited number of included RCTs. PROSPERO: CRD42024540121.
关于食用秋葵对血糖和血脂影响的临床研究结果并不一致。在本研究中，我们旨在探讨食用秋葵对成年人血糖参数和血脂水平的影响，包括胰岛素抵抗稳态模型评估（HOMA-IR）、糖化血红蛋白A1c（HbA1c）、空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。为了找到相关的随机对照试验（RCT），我们系统检索了截至2024年4月的EMBASE、科学网、PubMed、考克兰图书馆和Scopus数据库。根据纳入和排除标准，本研究最终纳入了8项涉及521名参与者的研究。与安慰剂相比，食用秋葵显著降低了成年人的空腹血糖（加权均数差：-32.56mg/dL；95%置信区间：-48.83，-16.28；P<0.001；I²=84.7%）、糖化血红蛋白A1c（加权均数差：-0.48%；95%置信区间：-0.81，-0.16；P=0.004；I²=5.5%）、甘油三酯（加权均数差：-13.16mg/dL；95%置信区间：-23.54，-2.77；P=0.013；I²=0.0%）和总胆固醇（加权均数差：-9.70mg/dL；95%置信区间：-14.95，-4.46；P<0.001；I²=38.3%）。然而，秋葵对胰岛素抵抗稳态模型评估、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇没有显著影响。食用秋葵对成年人的空腹血糖、糖化血红蛋白A1c、甘油三酯和总胆固醇水平有改善作用。由于纳入的随机对照试验数量有限，需要更多大规模的随机对照试验研究来验证秋葵对成年人的有益作用。国际前瞻性系统评价注册库：CRD42024540121。
