螺旋藻补充剂对血脂浓度影响的系统评价和荟萃分析。
A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
作者信息
Serban Maria-Corina, Sahebkar Amirhossein, Dragan Simona, Stoichescu-Hogea Gheorghe, Ursoniu Sorin, Andrica Florina, Banach Maciej
机构信息
Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
出版信息
Clin Nutr. 2016 Aug;35(4):842-51. doi: 10.1016/j.clnu.2015.09.007. Epub 2015 Sep 25.
BACKGROUND & AIMS: The impact of Spirulina supplementation on plasma lipid concentrations has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of Spirulina supplementation on plasma lipid concentrations.
METHODS
We searched PubMed and Scopus (up to July 03, 2015) to identify randomized controlled trials (RCTs) that investigate the effect Spirulina supplementation on plasma lipid concentrations. Meta-analysis and meta-regression were performed using random-effects models.
RESULTS
Random-effect meta-analysis of data from 7 RCTs showed a significant effect of supplementation with spirulina in reducing plasma concentrations of total cholesterol (WMD: -46.76 mg/dL, 95% CI: -67.31 to -26.22, p < 0.001), LDL-C (WMD: -41.32 mg/dL, 95% CI: -60.62 to -22.03, p < 0.001) and triglycerides (WMD: -44.23 mg/dL, 95% CI: -50.22 to -38.24, p < 0.001), and elevating those of HDL-C (WMD: 6.06 mg/dL, 95% CI: 2.37-9.76, p = 0.001). The impact of spirulina on plasma concentrations of total cholesterol (slope: -1.32; 95% CI: -8.58 to 5.93; p = 0.720), LDL-C (slope: -1.01; 95% CI: -8.03 to 6.02; p = 0.778), triglycerides (slope: -1.39; 95% CI: -4.26 to 1.48; p = 0.342) and HDL-C (slope: 1.79, 95% CI: -0.48 to 4.05; p = 0.122) was independent of administered dose. Regarding duration of supplementation with Spirulina, significant associations were found with changes in plasma concentrations of total cholesterol (slope: -1.77; 95% CI: -3.48 to -0.07; p = 0.042), LDL-C (slope: -1.73; 95% CI: -3.40 to -0.06; p = 0.042) HDL-C (slope: 0.91; 95% CI: 0.68-1.14; p < 0.001) and triglycerides (slope: -1.39; 95% CI: -2.28 to -0.50; p = 0.002).
CONCLUSIONS
This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C.
背景与目的
螺旋藻补充剂对血脂浓度的影响尚未得到最终定论。因此，本荟萃分析的目的是评估螺旋藻补充剂对血脂浓度的影响。
方法
我们检索了PubMed和Scopus（截至2015年7月3日），以确定研究螺旋藻补充剂对血脂浓度影响的随机对照试验（RCT）。使用随机效应模型进行荟萃分析和荟萃回归。
结果
对7项随机对照试验数据的随机效应荟萃分析表明，补充螺旋藻对降低总胆固醇（加权均数差：-46.76mg/dL，95%置信区间：-67.31至-26.22，p<0.001）、低密度脂蛋白胆固醇（加权均数差：-41.32mg/dL，95%置信区间：-60.62至-22.03，p<0.001）和甘油三酯（加权均数差：-44.23mg/dL，95%置信区间：-50.22至-38.24，p<0.001）的血浆浓度有显著影响，并能提高高密度脂蛋白胆固醇（加权均数差：6.06mg/dL，95%置信区间：2.37-9.76，p=0.001）的血浆浓度。螺旋藻对总胆固醇（斜率：-1.32；95%置信区间：-8.58至5.93；p=0.720）、低密度脂蛋白胆固醇（斜率：-1.01；95%置信区间：-8.03至6.02；p=0.778）、甘油三酯（斜率：-1.39；95%置信区间：-4.26至1.48；p=0.342）和高密度脂蛋白胆固醇（斜率：1.79，95%置信区间：-0.48至4.05；p=0.122）血浆浓度的影响与给药剂量无关。关于螺旋藻补充的持续时间，发现与总胆固醇（斜率：-1.77；95%置信区间：-3.48至-0.07；p=0.042）、低密度脂蛋白胆固醇（斜率：-1.73；95%置信区间：-3.40至-0.06；p=0.042）、高密度脂蛋白胆固醇（斜率：0.91；95%置信区间：0.68-1.14；p<0.001）和甘油三酯（斜率：-1.39；95%置信区间：-2.28至-0.50；p=0.002）的血浆浓度变化有显著关联。
结论
本荟萃分析表明，补充螺旋藻对降低总胆固醇、低密度脂蛋白胆固醇、甘油三酯的血浆浓度以及提高高密度脂蛋白胆固醇的血浆浓度有显著效果。
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