Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Rehabilitation Medicine, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Republic of Korea.
BMC Geriatr. 2023 Jun 1;23(1):346. doi: 10.1186/s12877-023-04063-1.
Spinal sarcopenia is a multifactorial disorder associated with atrophy and fatty changes in paraspinal muscles. Interventional studies for spinal sarcopenia are limited. We aimed to evaluate the effectiveness of a combined exercise and nutrition intervention for the treatment of spinal sarcopenia.
35 community-dwelling older women diagnosed with spinal sarcopenia in a previous cohort study were included. The 12-week combined intervention consisted of back extensor strengthening exercises and protein supplementation. The following outcomes were measured at baseline (week 0), after the intervention (week 12), and follow-up (week 24): conventional variables of sarcopenia (appendicular skeletal muscle mass, handgrip strength, 6-meter gait speed, and short physical performance battery); lumbar extensor muscle mass; lumbar extensor muscle volume and signal intensity; back extensor isokinetic strength; and back performance scale. We used the intention-to-treat analysis method, and repeated measures analysis of variance was used to analyze the data.
Of the total 35 potential participants, 26 older women participated in the study (mean age 72.5 ± 4.0 years old). After 12 weeks of combined exercise and nutrition intervention, there were no changes in the appendicular skeletal muscle mass, lumbar extensor muscle mass, volume, or signal intensity. Handgrip strength and back extensor isokinetic strength did not change significantly. Short physical performance battery significantly increased (P = 0.042) from 11.46 ± 0.86 to 11.77 ± 0.53 at week 12 and 11.82 ± 0.40 at week 24. The back performance scale sum score also significantly improved (P = 0.034) from 2.68 ± 1.81 to 1.95 ± 1.21 at week 12 and 2.09 ± 1.34 at week 24.
The combined exercise and nutrition intervention for community-dwelling older women with spinal sarcopenia could be feasible and helpful in improving the physical performance as well as back performance.
脊柱性肌肉减少症是一种与脊柱旁肌肉萎缩和脂肪变化相关的多因素疾病。针对脊柱性肌肉减少症的干预性研究有限。我们旨在评估联合运动和营养干预治疗脊柱性肌肉减少症的效果。
35 名在先前的队列研究中被诊断为脊柱性肌肉减少症的社区居住的老年女性参与了本研究。为期 12 周的联合干预包括背部伸肌强化锻炼和蛋白质补充。在基线（第 0 周）、干预后（第 12 周）和随访（第 24 周）时测量以下结果：肌少症的常规变量（四肢骨骼肌质量、握力、6 米步行速度和简短体能测试电池）；腰椎伸肌肌肉质量；腰椎伸肌肌肉体积和信号强度；背伸肌等速力量；以及背部表现量表。我们使用意向治疗分析方法，采用重复测量方差分析对数据进行分析。
在总共 35 名潜在参与者中，有 26 名老年女性参加了研究（平均年龄 72.5±4.0 岁）。经过 12 周的联合运动和营养干预，四肢骨骼肌质量、腰椎伸肌肌肉质量、体积或信号强度没有变化。握力和背伸肌等速力量没有显著变化。简短体能测试电池评分在第 12 周时显著增加（P=0.042），从 11.46±0.86 增加到 11.77±0.53，第 24 周时为 11.82±0.40。背部表现量表总分也显著改善（P=0.034），从第 12 周的 2.68±1.81 改善至 1.95±1.21，第 24 周时改善至 2.09±1.34。
针对社区居住的脊柱性肌肉减少症老年女性的联合运动和营养干预可能是可行且有益的，可改善身体机能和背部表现。
