Department of Rehabilitation Medicine.
Department of Radiology, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul.
Medicine (Baltimore). 2021 Jun 18;100(24):e26421. doi: 10.1097/MD.0000000000026421.
Spinal sarcopenia is a multifactorial disorder associated with the atrophy of and fatty changes to the paraspinal muscles. We previously developed the concept of spinal sarcopenia in community-dwelling older adults and investigated the association between conventional sarcopenic indices and spinal sarcopenia. However, interventional studies of spinal sarcopenia are lacking. This pilot study will aim to evaluate the effectiveness of a combined exercise and nutrition intervention for treating spinal sarcopenia.
This open-label single-arm prospective study will include 35 community-dwelling older women who were diagnosed with spinal sarcopenia in our previous cohort study. The 12-week combined intervention will consist of back extensor strengthening exercise and nutritional supplementation. The primary outcome of this study will be isometric back extensor strength after the 12-week intervention. All functional and radiographic outcomes will be measured at 0, 12, and 24 weeks post-intervention. The data will be analyzed using the intention-to-treat principle.
脊柱性肌肉减少症是一种与脊柱旁肌肉萎缩和脂肪变性相关的多因素疾病。我们之前在社区居住的老年人中提出了脊柱性肌肉减少症的概念，并研究了常规肌肉减少症指标与脊柱性肌肉减少症之间的关系。然而，针对脊柱性肌肉减少症的干预研究尚缺乏。本研究旨在评估综合运动和营养干预治疗脊柱性肌肉减少症的效果。
本开放标签单臂前瞻性研究将纳入 35 名在我们之前的队列研究中被诊断为脊柱性肌肉减少症的社区居住的老年女性。为期 12 周的联合干预措施将包括腰背伸肌强化运动和营养补充。本研究的主要结果将是 12 周干预后的等长腰背伸肌力量。所有功能和影像学结果将在干预后 0、12 和 24 周进行测量。数据将采用意向治疗原则进行分析。
