m6A 甲基化在癌症治疗抵抗中的作用。
The role of m6A methylation in therapy resistance in cancer.
机构信息
Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 21500, China.
Department of Radiotherapy, The Affiliated Jiangyin People's Hospital of Nantong University, Jiangyin, 214400, China.
出版信息
Mol Cancer. 2023 Jun 1;22(1):91. doi: 10.1186/s12943-023-01782-2.
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation. A large number of studies have shown that m6A RNA methylation regulates the proliferation and invasion of cancer cells, but the role of m6A in cancer therapy resistance is unclear. In this review, we summarized the research progress related to the role of m6A in regulating therapy resistance in cancers.
癌症治疗耐药性是癌症治疗失败的主要原因。治疗耐药性的机制是表观遗传学的热门话题。作为最常见的 RNA 修饰之一，N6-甲基腺苷（m6A）参与 RNA 代谢的各种过程，如稳定性、剪接、转录、翻译和降解。大量研究表明，m6A RNA 甲基化调节癌细胞的增殖和侵袭，但 m6A 在癌症治疗耐药性中的作用尚不清楚。在这篇综述中，我们总结了与 m6A 调节癌症治疗耐药性相关的研究进展。
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