Li Guanlin, Li Zehao, Min Yajun, Chen Shilu, Han Ruijia, Zhao Zheng
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China.
Sanya Science and Education Innovation Park of Wuhan University of Technology, Sanya, 572000, China.
Small. 2023 Oct;19(40):e2302927. doi: 10.1002/smll.202302927. Epub 2023 Jun 1.
The application of piezoelectric nanoparticles with shape memory polymer (SMP) to 3D-printed piezoelectric scaffolds for bone defect repair is an attractive research direction. However, there is a significant difference in dielectric constants between the piezoelectric phase and polymer phase, limiting the piezoelectric property. Therefore, novel piezoelectric acrylate epoxidized soybean oil (AESO) scaffolds doped with piezoelectric Ag-TMSPM-pBT (ATP) nanoparticles (AESO-ATP scaffolds) are prepared via digital light procession 3D-printing. The Ag-TMSPM-pBT nanoparticles improve the piezoelectric properties of the AESO scaffolds by TMSPM covalent functionalization and conductive Ag nanoparticles. The AESO scaffolds doped with 10 wt% Ag-TMSPM-pBT nanoparticles (AESO-10ATP scaffolds) exhibit promising piezoelectrical properties, with a piezoelectric coefficient (d33) of 0.9 pC N and an output current of 146.4 nA, which are close to the piezoelectric constants of bone tissue. In addition, these scaffolds exhibit good shape memory function and can quickly recover their original shape under near-infrared (NIR) light irradiation. The results of osteogenesis capability evaluation indicate that the AESO-10ATP scaffolds can promote osteogenic differentiation of BMSCs in vitro and bone defect repair in vivo, indicating the 3D-printed AESO-10ATP piezoelectric scaffolds may have great application potential for bone regeneration.
将具有形状记忆聚合物（SMP）的压电纳米颗粒应用于3D打印的骨缺损修复压电支架是一个有吸引力的研究方向。然而，压电相和聚合物相之间的介电常数存在显著差异，限制了压电性能。因此，通过数字光处理3D打印制备了掺杂压电Ag-TMSPM-pBT（ATP）纳米颗粒的新型压电丙烯酸环氧大豆油（AESO）支架（AESO-ATP支架）。Ag-TMSPM-pBT纳米颗粒通过TMSPM共价功能化和导电Ag纳米颗粒提高了AESO支架的压电性能。掺杂10 wt% Ag-TMSPM-pBT纳米颗粒的AESO支架（AESO-10ATP支架）表现出良好的压电性能，压电系数（d33）为0.9 pC/N，输出电流为146.4 nA，接近骨组织的压电常数。此外，这些支架表现出良好的形状记忆功能，在近红外（NIR）光照射下能快速恢复其原始形状。成骨能力评估结果表明，AESO-10ATP支架在体外可促进骨髓间充质干细胞（BMSCs）的成骨分化，在体内可促进骨缺损修复，表明3D打印的AESO-10ATP压电支架在骨再生方面可能具有巨大的应用潜力。
