丙烯酸酯化环氧大豆油基生物材料的生物降解研究：一项体外研究。
Biodegradation Study of Biomaterials Composed of Acrylated Epoxidized Soybean Oil: An In Vitro Study.
作者信息
Sibilia Diego, Amendolea Martina, Sangiovanni Roberta, Bragaglia Mario, Nicoletti Fabrizio, Filetici Pierfrancesco, D'Addona Antonio, Nanni Francesca, Dassatti Leonardo, Nocca Giuseppina
机构信息
Dipartimento di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Largo F. Vito, 1 00168, Rome, Italy.
Head and Neck Department, School of Dentistry, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, Rome 00168, Italy.
出版信息
Biomed Res Int. 2024 Nov 22;2024:7100988. doi: 10.1155/bmri/7100988. eCollection 2024.
In the field of regenerative medicine, acrylated epoxidized vegetable oils are emerging as a promising avenue of exploration. The aim of this study is to evaluate the degradability of two formulations of acrylated epoxidized soybean oil (AESO): pure AESO and AESO diluted with soybean oil (SO) for potential bioprintability applications. The comprehensive investigation of these two polymeric formulations included optimization of polymerization conditions, confirmation of cytocompatibility, and, most importantly, the study of their degradability. The results reveal that AESO, used as a biomaterial for biomedical applications, undergoes a distinctive degradation process, combining both enzymatic and oxidative degradation (AESO/SO samples lose 29.45% of their weight after 60 days). This phenomenon is the result of a complex interplay of factors, including the chemical composition and physical characteristics of the polymer, the unique tissue environment in which it is implanted, and the duration of implantation.
在再生医学领域，丙烯酸化环氧化植物油正成为一个有前景的探索方向。本研究的目的是评估两种丙烯酸化环氧化大豆油（AESO）配方的可降解性：纯AESO和用大豆油（SO）稀释的AESO，用于潜在的生物打印应用。对这两种聚合物配方的全面研究包括聚合条件的优化、细胞相容性的确认，以及最重要的，它们的可降解性研究。结果表明，用作生物医学应用生物材料的AESO经历了独特的降解过程，结合了酶促降解和氧化降解（AESO/SO样品在60天后失重29.45%）。这种现象是多种因素复杂相互作用的结果，包括聚合物的化学成分和物理特性、植入的独特组织环境以及植入持续时间。
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