Nordan R P, Potter M
Science. 1986 Aug 1;233(4763):566-9. doi: 10.1126/science.3726549.
Plasmacytoma (PCT) cell lines dependent for proliferation and survival on a factor elaborated by the murine macrophage cell line, P388D1, were established in vitro. Adherent peritoneal cells induced by pristane produced 50-fold greater amounts of this activity in vitro than did resident cells. The molecules responsible for plasmacytoma growth were distinct from a number of characterized factors including interleukin-1, -2, and -3, macrophage colony-stimulating factor, B-cell stimulatory factor-1, B-cell growth factor II, epidermal growth factor, transforming growth factor-beta, and gamma- and beta-interferon, none of which were able to support the growth of the factor-dependent PCT cell lines. These results suggest that PCT growth factor may be a novel factor that has not been previously characterized and, further, that its production is associated with the pristane-induced, chronic peritoneal inflammatory response that precedes plasmacytoma formation.
依赖于鼠巨噬细胞系P388D1所产生的一种因子进行增殖和存活的浆细胞瘤（PCT）细胞系在体外建立。由 pristane诱导的贴壁腹膜细胞在体外产生的这种活性比常驻细胞高50倍。负责浆细胞瘤生长的分子与多种已鉴定的因子不同，包括白细胞介素-1、-2和-3、巨噬细胞集落刺激因子、B细胞刺激因子-1、B细胞生长因子II、表皮生长因子、转化生长因子-β以及γ和β干扰素，这些因子均无法支持依赖该因子的PCT细胞系的生长。这些结果表明，PCT生长因子可能是一种以前未被鉴定的新因子，而且其产生与浆细胞瘤形成之前由pristane诱导的慢性腹膜炎症反应有关。
