Babenko N A
Ukr Biokhim Zh (1978). 1986 May-Jun;58(3):40-7.
The content of polyenic fatty acids in lipids of nuclear membranes and chromatin of albino rat liver cells is established to decrease considerably in the process of ageing. It is also shown that the RNA-polymerase activity lowers with the animal age. With an increase of the content of polyunsaturated fatty acids in lipids of nuclear structures of liver cells in old animals with the aid of diet and phospholipid liposomes the RNA-polymerase activity enhances up to the level of young rats aged three months and older. However, if the relative content of polyunsaturated fatty acids in lipids of old test rats decreases with the aid of the diet to the level of the control rats aged 26 months, then the activity of RNA-polymerases falls to the level of activity in control rats of the given age group and younger.
已确定，白化大鼠肝细胞的核膜和染色质脂质中的多烯脂肪酸含量在衰老过程中会大幅下降。研究还表明，RNA聚合酶活性会随着动物年龄的增长而降低。在老年动物中，通过饮食和磷脂脂质体增加肝细胞核结构脂质中多不饱和脂肪酸的含量后，RNA聚合酶活性可提高到三个月及以上幼鼠的水平。然而，如果通过饮食使老年受试大鼠脂质中多不饱和脂肪酸的相对含量降至26个月龄对照大鼠的水平，那么RNA聚合酶的活性就会降至该年龄组及更年轻对照大鼠的活性水平。
