Institute of Anesthesiology and Critical Care Medicine, Three Gorges University & Yichang Central People's Hospital, No. 183 Yiling Avenue, Wujiagang District, 443000, Yichang City, Hubei, China.
BMC Anesthesiol. 2023 Jun 3;23(1):192. doi: 10.1186/s12871-023-02152-7.
Anesthesia with opioids negatively affects patients' quality of recovery. Opioid-free anesthesia attempts to avoid these effects. This study aimed to evaluate the effect of opioid-free anesthesia on the quality of recovery, using lidocaine on patients undergoing hysteroscopy.
A parallel-group, randomized, double-blind, controlled trial was conducted in Yichang Central Peoples' Hospital, Hubei Province, China, from January to April, 2022. We included 90 female patients (age: 18-65 years, American Society of Anesthesiologists Physical Status Class I-II) scheduled for elective hysteroscopy, 45 of whom received lidocaine (Group L), and 45 received sufentanil (Group S). Patients were randomly allocated to receive either lidocaine or sufentanil perioperatively. The primary outcome was the quality of postoperative recovery, which was assessed using the QoR-40 questionnaire (a patient-reported outcome questionnaire measuring the quality of recovery after surgery).
The two groups were similar in age, American Society of Anesthesiology physical status, height, weight, body mass index, and surgical duration. The QoR scores were significantly higher in Group L than Group S. The incidence of postoperative nausea and vomiting, as well as the time to extubation were significantly lower in Group L than Group S.
Opioid-free anesthesia with lidocaine achieves a better quality of recovery, faster recovery, and a shorter time to extubation than general anesthesia with sufentanil.
The trial was registered on January 15, 2022 in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/showprojen.aspx?proj=149386 ), registration number ChiCTR2200055623.(15/01/2022).
阿片类药物麻醉会降低患者的康复质量。无阿片类药物麻醉试图避免这些影响。本研究旨在评估利多卡因用于宫腔镜检查患者的无阿片类药物麻醉对康复质量的影响。
一项平行组、随机、双盲、对照试验于 2022 年 1 月至 4 月在湖北省宜昌市中心人民医院进行。纳入 90 名年龄在 18-65 岁、美国麻醉医师协会身体状况 I-II 级的择期行宫腔镜检查的女性患者，其中 45 名患者接受利多卡因（L 组），45 名患者接受舒芬太尼（S 组）。患者被随机分配接受围手术期利多卡因或舒芬太尼。主要结局是使用 QoR-40 问卷（一种衡量手术后恢复质量的患者报告结局问卷）评估的术后恢复质量。
两组患者的年龄、美国麻醉医师协会身体状况、身高、体重、体重指数和手术时间相似。L 组的 QoR 评分明显高于 S 组。L 组术后恶心呕吐发生率及拔管时间明显低于 S 组。
与舒芬太尼全身麻醉相比，无阿片类药物麻醉联合利多卡因可获得更好的康复质量、更快的恢复和更短的拔管时间。
该试验于 2022 年 1 月 15 日在中国临床试验注册中心（http://www.chictr.org.cn/showprojen.aspx?proj=149386）注册，注册号 ChiCTR2200055623。（2022 年 1 月 15 日）。
