Yasmeen Ayesha, Syed Mamoon H, Alqahtani Saad S, Kashan Syed Nabeel, Meraya Abdulkarim M, Wazaify Mayyada, Van Hout Marie-Claire
Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
Pharmacy Practice Research Unit, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
Saudi Pharm J. 2023 Jul;31(7):1254-1264. doi: 10.1016/j.jsps.2023.05.009. Epub 2023 May 15.
Inappropriate use of medications is a global health concern, and this is attributed to the increased accessibility to prescription and non-prescription (over-the-counter) drugs at community pharmacies. We investigated the inappropriate use of prescription and non-prescription drugs in community pharmacies based on the perspectives of the community pharmacists in Saudi Arabia.
This was a questionnaire-based, cross-sectional survey which employed convenient sampling (snowball technique) to recruit participants. Being a licensed practicing pharmacist in a retail chain or an independent community pharmacy was the inclusion criteria. Participants were asked to report the drugs they suspected of being inappropriately used along with the frequency, age and gender of the suspected customers. Pharmacists were also asked to mention the action taken to limit inappropriate use at their pharmacy.
A total of 397 community pharmacists completed the questionnaire (86.9 % response rate). 86.4% of the pharmacists suspected some level of abuse or misuse to have occurred. After receiving the questionnaire, the pharmacists reported suspected inappropriate use as encountered during the past three months. Cumulative inappropriate use was reported 1069 times (prescription drugs - 530; non-prescription drugs - 539). The top three inappropriately used prescription-drug categories were gabapentinoids (22.5%), antipsychotics (17.5%) and topical corticosteroids (12.1%). Among non-prescription drugs, cough products (33.2%) ranked first, followed by cold and flu products (29.5%) and first-generation antihistamines (10.8%). The cross tabulations revealed that being in the age range of 26-50 years and being a male was significantly associated (p < 0.001) with abuse/misuse of antipsychotics, antidepressants, gabapentinoids, cough products and first-generation antihistamines. Eye products (Bimatoprost) and skin products abuse/misuse had significant association with female gender (p < 0.001).
The results of our study provide crucial information to the healthcare authorities regarding the medications that can be inappropriately used at the community pharmacies in Saudi Arabia which necessitates implementation of stringent dispensing regulations. Educational programs can be implemented to increase the awareness among public regarding the harmful effects of inappropriate use of drugs.
药物的不当使用是一个全球健康问题,这归因于社区药房中处方药和非处方药(非处方/柜台发售)获取的便利性增加。我们基于沙特阿拉伯社区药剂师的视角,调查了社区药房中处方药和非处方药的不当使用情况。
这是一项基于问卷的横断面调查,采用便利抽样(滚雪球技术)招募参与者。纳入标准是在零售连锁药店或独立社区药房中持有执业药师执照。要求参与者报告他们怀疑使用不当的药物以及可疑顾客的频率、年龄和性别。药剂师还被要求提及在其药房采取的限制不当使用的措施。
共有397名社区药剂师完成了问卷(回复率为86.9%)。86.4%的药剂师怀疑发生了某种程度的滥用或误用。收到问卷后,药剂师报告了过去三个月中遇到的可疑不当使用情况。累计报告不当使用1069次(处方药 - 530次;非处方药 - 539次)。使用不当的处方药类别排名前三的是加巴喷丁类药物(22.5%)、抗精神病药物(17.5%)和外用皮质类固醇(12.1%)。在非处方药中,止咳产品(33.2%)排名第一,其次是感冒和流感产品(29.5%)以及第一代抗组胺药(10.8%)。交叉列表显示,年龄在26 - 50岁之间且为男性与抗精神病药物、抗抑郁药物、加巴喷丁类药物、止咳产品和第一代抗组胺药的滥用/误用显著相关(p < 0.001)。眼部产品(比马前列素)和皮肤产品的滥用/误用与女性性别显著相关(p < 0.001)。
我们的研究结果为卫生保健当局提供了关于沙特阿拉伯社区药房中可能被不当使用的药物的关键信息,这需要实施严格的配药规定。可以实施教育项目以提高公众对不当使用药物有害影响的认识。