隔日改良禁食饮食可改善肥胖或超重女性的体重减轻、主观睡眠质量和日间功能障碍：一项随机对照试验。
Alternate-day modified fasting diet improves weight loss, subjective sleep quality and daytime dysfunction in women with obesity or overweight: a randomized, controlled trial.
作者信息
Hooshiar Saeedeh Hosseini, Yazdani Akram, Jafarnejad Sadegh
机构信息
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Department of Biostatistics and Epidemiology, Kashan University of Medical Sciences, Kashan, Iran.
出版信息
Front Nutr. 2023 May 18;10:1174293. doi: 10.3389/fnut.2023.1174293. eCollection 2023.
BACKGROUND
Both sleep time and quality can be associated with overweight or obesity. In obese people, visceral fat tissue develops, which results in an increment in the production of cytokines. The increased production of inflammatory cytokines can disturb the sleep/wake cycle. Therefore, weight loss by reducing fat tissue can improve sleep disorders. Intermittent fasting diets are popular and effective diets that can decrease body weight and improve anthropometric data and body composition. The present study aimed to evaluate the effect of Alternate-day Modified Fasting (ADMF) on sleep quality, body weight, and daytime sleepiness.
METHODS
Classification of 56 obese or overweight women, based on age and body mass index (BMI), was done using stratified randomization. Then individuals were assigned to the ADMF group (intervention) or Daily Calorie Restriction (CR) group (control) using the random numbers table for 8 weeks. We measured the Pittsburgh sleep quality Index (PSQI), weight, BMI, and the Epworth sleepiness scale (ESS) as primary outcomes and assessed subjective sleep quality (SSQ), sleep latency, sleep disturbances, habitual sleep efficiency, daytime dysfunction, and sleep duration as secondary outcomes at baseline and after the study.
RESULTS
Following an ADMF diet resulted in a greater decrease in weight (kg) [-5.23 (1.73) vs. -3.15 (0.88); < 0.001] and BMI (kg/m) [-2.05 (0.66) vs. -1.17 (0.34); < 0.001] compared to CR. No significant differences were found in the changes of PSQI [-0.39 (1.43) vs. -0.45 (1.88); = 0.73] and ESS [-0.22 (1.24) vs. -0.54 (1.67); = 0.43] between two groups. Also, following the ADMF diet led to significant changes in SSQ [-0.69 (0.47) vs. -0.08 (0.40); = <0.001], and daytime dysfunction [-0.65 (0.57) vs. 0.04 (0.75); : 0.001] in compare with CR diet.
CONCLUSION
These results suggested that an ADMF could be a beneficial diet for controlling body weight and BMI. The ADMF diet didn't affect PSQI and ESS in women with overweight or obesity but significantly improved SSQ and daytime dysfunction.
CLINICAL TRIAL REGISTRATION
The Iranian Registry of Clinical Trials (IRCT20220522054958N3), https://www.irct.ir/trial/64510.
背景
睡眠时间和质量都可能与超重或肥胖有关。在肥胖人群中，内脏脂肪组织会发展，这会导致细胞因子产生增加。炎症细胞因子产生的增加会扰乱睡眠/觉醒周期。因此，通过减少脂肪组织来减轻体重可以改善睡眠障碍。间歇性禁食饮食是流行且有效的饮食方式，可减轻体重并改善人体测量数据和身体成分。本研究旨在评估隔日改良禁食（ADMF）对睡眠质量、体重和日间嗜睡的影响。
方法
根据年龄和体重指数（BMI），采用分层随机化对56名肥胖或超重女性进行分类。然后使用随机数字表将个体分为ADMF组（干预组）或每日热量限制（CR）组（对照组），为期8周。我们测量了匹兹堡睡眠质量指数（PSQI）、体重、BMI和爱泼华嗜睡量表（ESS）作为主要结局，并在基线和研究结束后评估主观睡眠质量（SSQ）、睡眠潜伏期、睡眠障碍、习惯性睡眠效率、日间功能障碍和睡眠时间作为次要结局。
结果
与CR组相比，采用ADMF饮食导致体重（kg）下降幅度更大[-5.23（1.73）对-3.15（0.88）；P<0.001]，BMI（kg/m²）下降幅度更大[-2.05（0.66）对-1.17（0.34）；P<0.001]。两组之间PSQI的变化[-0.39（1.43）对-0.45（1.88）；P = 0.73]和ESS的变化[-0.22（1.24）对-0.54（1.67）；P = 0.43]无显著差异。此外，与CR饮食相比，采用ADMF饮食导致SSQ发生显著变化[-0.69（0.47）对-0.08（0.40）；P<0.001]，以及日间功能障碍发生显著变化[-0.65（0.57）对0.04（0.75）；P = 0.001]。
结论
这些结果表明，ADMF可能是一种控制体重和BMI的有益饮食。ADMF饮食对超重或肥胖女性的PSQI和ESS没有影响，但显著改善了SSQ和日间功能障碍。
临床试验注册
伊朗临床试验注册中心（IRCT20220522054958N3），https://www.irct.ir/trial/64510 。
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