Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran.
Assistant Professor of Nutrition. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Complement Ther Med. 2019 Dec;47:102187. doi: 10.1016/j.ctim.2019.08.021. Epub 2019 Aug 28.
The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome.
This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome.
Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate-day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion.
69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P = 0.003), waist circumference (P = 0.026), systolic blood pressure (P = 0.029) and fasting plasma glucose (P = 0.009). However, no significant difference was observed between the 2 groups in triglyceride (P = 0.614), total cholesterol (P = 0.759), LDL-C (P = 0.289), HDL-C (P = 0.909), diastolic blood pressure (P = 0.262), HOMA- IR (P = 0.425) and fasting insulin concentrations (P = 0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet.
the present study suggests that modified alternate-day fasting diet may be a more effective option in managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results.
本研究旨在比较热量限制和改良隔日禁食饮食对代谢综合征成人患者的治疗效果。
本随机临床试验纳入了 70 名代谢综合征患者。
患者被随机分为两组，分别遵循热量限制或改良隔日禁食饮食 8 周。营养师为每位参与者制定了专门的饮食计划。在基线和试验结束时，测量了人体测量学参数、血压、空腹血糖、空腹胰岛素、HOMA-IR 和血脂谱。
在 70 名参与者中，有 69 名完成了研究并纳入最终分析。结果表明，与热量限制相比，改良隔日禁食饮食可显著降低体重（P=0.003）、腰围（P=0.026）、收缩压（P=0.029）和空腹血糖（P=0.009）。然而，两组间在甘油三酯（P=0.614）、总胆固醇（P=0.759）、LDL-C（P=0.289）、HDL-C（P=0.909）、舒张压（P=0.262）、HOMA-IR（P=0.425）和空腹胰岛素浓度（P=0.496）方面无显著差异。此外，当参与者遵循热量限制或改良隔日禁食饮食时，均未报告因饮食依从性困难而产生的不适。
与常见的热量限制相比，改良隔日禁食饮食可能是管理体重、腰围、收缩压和空腹血糖的更有效选择。需要进一步的研究来证实我们研究结果的真实性。
