（施温夫）哈姆斯（楝科）和L.（铁青树科）水乙醇提取物的抗溃疡作用

Antiulcer Effect of Aqueous Ethanolic Extracts of (Schweinf) Harms (Meliaceae) and L. (Olacaceae).

作者信息

Delma Edwige T, Ouédraogo Moussa, Ouédraogo Aimé S, Nikiema Arsène W, Abdoulaye Gambo Moustapha, Ramde Norbert, Youl Estelle N H, Sanou-Lamien Assita, Lompo Olga Mélanie, Guissou Pierre I

机构信息

Laboratoire de Développement du Médicament, Ecole Doctorale Sciences et Santé (ED2S), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.

Faculté des Sciences de la Santé, Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso.

出版信息

J Exp Pharmacol. 2023 May 29;15:231-240. doi: 10.2147/JEP.S393168. eCollection 2023.

DOI:10.2147/JEP.S393168

PMID:37275787

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10237205/

Abstract

PURPOSE

This study aimed to provide pharmacological evidence of and in preventing or healing peptic ulcers claimed by traditional healers in Burkina Faso.

METHODS

The trunk bark of and the roots bark of (Olacaceae) were macerated in mixed ethanol/water (80:20), respectively, to obtain dried extracts. Two models of hydrochloric acid (HCl, 0.3 M/ethanol, 60%) and hypothermic stress-induced peptic ulcer were used. The cytoprotective effect of individual or combined plant extracts was assessed at 1; 10; 30mg/kg. bw. Then, the healing effect of the extracts at 10mg/kg.bw was evaluated within 21 days of treatment on the hydrochloric acid-induced ulcer model. The extracts' antioxidant activity and phenolic content were assessed to support the plant extracts' efficiency.

RESULTS

The extracts of and at 10 mg/kg.bw reduced ulceration index in hydrochloric acid- and hypothermic stress-ulcer models by more than 83% and 65%, respectively. The extract from at 10mg/kg.bw allowed complete ulcer healing but not the association of the two plant extracts. The plant extracts had ICof inhibition of DPPH radical lower than 5μg/mL and total ferric reducing antioxidant power of more than 77 mg EQAA/100mg. The total polyphenolic content was 64.82 ±0.99 and 53.75 ±1.39 mg EGA/g of dried extract of and , respectively.

CONCLUSION

extract is better than the combined two plant extracts in gastric cytoprotection and ulcer healing. Further investigations are needed to highlight mechanism-based effects.

摘要

目的

本研究旨在为布基纳法索传统治疗师声称的[植物名称1]和[植物名称2]预防或治愈消化性溃疡提供药理学证据。

方法

分别将[植物名称1]的树干树皮和[植物名称2]（铁青树科）的根皮在乙醇/水（80:20）混合液中浸渍，以获得干燥提取物。使用两种模型，即盐酸（HCl，0.3 M/乙醇，60%）和低温应激诱导的消化性溃疡模型。以1、10、30mg/kg体重评估单一或组合植物提取物的细胞保护作用。然后，在盐酸诱导的溃疡模型治疗21天内，评估10mg/kg体重提取物的愈合效果。评估提取物的抗氧化活性和酚类含量以支持植物提取物的有效性。

结果

10mg/kg体重的[植物名称1]和[植物名称2]提取物在盐酸和低温应激溃疡模型中分别使溃疡指数降低超过83%和65%。10mg/kg体重的[植物名称1]提取物可使溃疡完全愈合，但两种植物提取物的组合则不能。植物提取物对DPPH自由基的IC50抑制低于5μg/mL，总铁还原抗氧化能力超过77mg EQAA/100mg。[植物名称1]和[植物名称2]干燥提取物的总多酚含量分别为64.82±0.99和53.75±1.39mg EGA/g。