Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Pharmacognosy Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Malaysia.
Pharm Biol. 2021 Dec;59(1):955-963. doi: 10.1080/13880209.2021.1950776.
(Schweinf) Harms (Meliaceae) is an important medicinal plant found in tropical and subtropical countries of Africa. Traditionally, is used in the treatment of various diseases including diabetes, malaria, abdominal pain and diarrhoea.
To provide an overview of traditional medicinal claims, pharmacological properties, and phytochemical principles of as a basis for its clinical applications and further research and development of new drugs.
Through interpreting already published scientific manuscripts retrieved from different scientific search engines, namely, Medline, PubMed, EMBASE, Science Direct and Google scholar databases, an up-to-date review on the medicinal potentials of from inception until September, 2020 was compiled. '', 'traditional uses', 'pharmacological properties' and 'chemical constituents' were used as search words.
At present, more than 30 chemical constituents have been isolated and identified from the root and stem bark of , among which limonoids and triterpenes are the main active constituents. Based on prior research, has been reported to possess anti-inflammatory, analgesic, antipyretic, anthelminthic, antimalaria, anti-leishmaniasis, anti-trypanosomiasis, hepatoprotective, antioxidant, antidiabetic, antidiarrheal, antimicrobial, and anticancer effects.
is reported to be effective in treating a variety of diseases. Current phytochemical and pharmacological studies mainly focus on antimalaria, anti-leishmaniasis, anti-trypanosomiasis and anticancer potential of the root and stem bark of . Although experimental data support the beneficial medicinal properties of this plant, there is still a paucity of information on its toxicity profile. Nonetheless, this review provides the basis for future research work.
（Schweinf）哈姆斯（楝科）是一种重要的药用植物，分布在非洲的热带和亚热带国家。传统上，它被用于治疗各种疾病，包括糖尿病、疟疾、腹痛和腹泻。
为了提供的传统药用主张、药理特性和植物化学原理的概述，作为其临床应用和进一步研究和开发新药的基础。
通过解释已经从不同的科学搜索引擎，即 Medline、PubMed、EMBASE、Science Direct 和 Google 学者数据库检索到的已发表的科学文献，对截至 2020 年 9 月的药用潜力进行了最新的综述。使用了“”、“传统用途”、“药理性质”和“化学成分”作为搜索词。
目前，已经从根和茎皮中分离和鉴定出超过 30 种化学成分，其中主要的活性成分是柠檬苦素和三萜。根据之前的研究，已经报道具有抗炎、镇痛、解热、驱虫、抗疟、抗利什曼病、抗锥虫病、保肝、抗氧化、抗糖尿病、抗腹泻、抗菌和抗癌作用。
据报道，它在治疗多种疾病方面是有效的。目前的植物化学和药理学研究主要集中在根和茎皮的抗疟、抗利什曼病、抗锥虫病和抗癌潜力上。尽管实验数据支持这种植物具有有益的药用特性，但关于其毒性特征的信息仍然很少。然而，这篇综述为未来的研究工作提供了基础。
