Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India; Jyoti and Bhupat Mehta School of Health Sciences and Technology, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.
Curr Opin Chem Biol. 2023 Aug;75:102337. doi: 10.1016/j.cbpa.2023.102337. Epub 2023 Jun 3.
Cellular redox homeostasis is very important for the overall cellular development, function, and oxidative stress often disrupts the process. Small-molecule organoselenium compounds exert key roles in maintaining the redox homeostasis during oxidative stress and cancer owing to their notable antioxidant activities. Among different organoselenium compounds, small-molecule organoselenocyanates have attracted much research attention due to their synthetic utilities and therapeutic potentials. Therefore, the development of convenient synthetic methodologies to different classes of organoselenocyanates from various precursors was explored over the years as useful synthetic building blocks. Additionally, considering their inherent redox and antioxidant properties, the development of biologically relevant organoselenocyanates upon their conjugation with the existing drugs and natural products has been chosen for enhancing the drug potencies and in ameliorating the drug-induced side-effects. In the present report, we have discussed some of the very recent and relevant developments on these aspects in a very concise manner.
细胞氧化还原稳态对细胞的整体发育、功能非常重要，氧化应激常常会破坏这一过程。小分子有机硒化合物由于其显著的抗氧化活性，在氧化应激和癌症中维持氧化还原稳态方面发挥着关键作用。在不同的有机硒化合物中，小分子有机硒氰酸酯由于其合成用途和治疗潜力而引起了广泛的研究关注。因此，多年来一直在探索从各种前体制备不同类别的有机硒氰酸酯的方便合成方法，作为有用的合成砌块。此外，考虑到其固有的氧化还原和抗氧化特性，通过与现有药物和天然产物的结合来开发具有生物学相关性的有机硒氰酸酯，以提高药物效力并改善药物引起的副作用，已成为一种选择。在本报告中，我们以非常简洁的方式讨论了这些方面的一些最新和相关的进展。
