美国成年人中阻塞性睡眠呼吸暂停与 COVID-19 感染和住院之间的关联。

Associations between obstructive sleep apnea and COVID-19 infection and hospitalization among US adults.

机构信息

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.

Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts.

出版信息

J Clin Sleep Med. 2023 Jul 1;19(7):1303-1311. doi: 10.5664/jcsm.10588.

DOI:10.5664/jcsm.10588

PMID:37279079

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10315594/

Abstract

STUDY OBJECTIVES

Medical comorbidities increase the risk of severe COVID-19 infection. In some studies, obstructive sleep apnea (OSA) has been identified as a comorbid condition that is associated with an increased prevalence of COVID-19 infection and hospitalization, but few have investigated this association in a general population. This study aimed to answer the following research question: In a general population, is OSA associated with increased odds of COVID-19 infection and hospitalization and are these altered with COVID-19 vaccination?

METHODS

This was a cross-sectional survey of a diverse sample of 15,057 US adults.

RESULTS

COVID-19 infection and hospitalization rates in the cohort were 38.9% and 2.9%, respectively. OSA or OSA symptoms were reported in 19.4%. In logistic regression models adjusted for demographic, socioeconomic, and comorbid medical conditions, OSA was positively associated with COVID-19 infection (adjusted odds ratio: 1.58, 95% CI: 1.39-1.79) and COVID-19 hospitalization (adjusted odds ratio: 1.55, 95% CI: 1.17-2.05). In fully adjusted models, boosted vaccination status was protective against both infection and hospitalization. Boosted vaccination status attenuated the association between OSA and COVID-19 related hospitalization but not infection. Participants with untreated or symptomatic OSA were at greater risk for COVID-19 infection; those with untreated but not symptomatic OSA were more likely to be hospitalized.

CONCLUSIONS

In a general population sample, OSA is associated with a greater likelihood of having had a COVID-19 infection and a COVID-19 hospitalization with the greatest impact observed among persons experiencing OSA symptoms or who were untreated for their OSA. Boosted vaccination status attenuated the association between OSA and COVID-19-related hospitalization.

CITATION

Quan SF, Weaver MD, Czeisler MÉ, et al. Associations between obstructive sleep apnea and COVID-19 infection and hospitalization among U.S. adults. . 2023;19(7):1303-1311.

摘要

研究目的

医学合并症会增加严重 COVID-19 感染的风险。在一些研究中，阻塞性睡眠呼吸暂停（OSA）已被确定为一种合并症，与 COVID-19 感染和住院的患病率增加有关，但很少有研究在一般人群中调查这种关联。本研究旨在回答以下研究问题：在一般人群中，OSA 是否与 COVID-19 感染和住院的几率增加有关，而 COVID-19 疫苗接种是否会改变这种关联？

方法

这是一项针对 15057 名美国成年人的多元化样本的横断面调查。

结果

队列中 COVID-19 感染和住院率分别为 38.9%和 2.9%。报告了 19.4%的 OSA 或 OSA 症状。在调整了人口统计学、社会经济和合并医疗条件的逻辑回归模型中，OSA 与 COVID-19 感染（调整后的优势比：1.58，95%置信区间：1.39-1.79）和 COVID-19 住院（调整后的优势比：1.55，95%置信区间：1.17-2.05）呈正相关。在完全调整的模型中，加强疫苗接种状态对感染和住院都有保护作用。加强疫苗接种状态减弱了 OSA 与 COVID-19 相关住院之间的关联，但对感染没有影响。未经治疗或有症状的 OSA 患者患 COVID-19 感染的风险更高；未经治疗但无症状的 OSA 患者更有可能住院。