Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, M5T2S8, Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada.
Sleep Breath. 2021 Jun;25(2):849-860. doi: 10.1007/s11325-021-02373-5. Epub 2021 Apr 28.
Obstructive sleep apnea (OSA) may increase the risk of severe COVID-19; however, the level of potential modulation has not yet been established. The objective of the study was to determine the association between high risk of OSA, comorbidities, and increased risk for COVID-19, hospitalization, and intensive care unit (ICU) treatment.
We conducted a cross-sectional population-based web survey in adults in 14 countries/regions. The survey included sociodemographic variables and comorbidities. Participants were asked questions about COVID-19, hospitalization, and ICU treatment. Standardized questionnaire (STOP questionnaire for high risk of OSA) was included. Multivariable logistic regression was conducted adjusting for various factors.
Out of 26,539 respondents, 20,598 (35.4% male) completed the survey. Mean age and BMI of participants were 41.5 ± 16.0 years and 24.0 ± 5.0 kg/m, respectively. The prevalence of physician-diagnosed OSA was 4.1% and high risk of OSA was 9.5%. We found that high risk of OSA (adjusted odds ratio (aOR) 1.72, 95% confidence interval (CI): 1.20, 2.47) and diabetes (aOR 2.07, 95% CI: 1.23, 3.48) were associated with reporting of a COVID-19 diagnosis. High risk for OSA (aOR 2.11, 95% CI: 1.10-4.01), being male (aOR: 2.82, 95% CI: 1.55-5.12), having diabetes (aOR: 3.93, 95% CI: 1.70-9.12), and having depression (aOR: 2.33, 95% CI: 1.15-4.77) were associated with increased risk of hospitalization or ICU treatment.
Participants at high risk of OSA had increased odds of having COVID-19 and were two times more likely to be hospitalized or treated in ICU.
阻塞性睡眠呼吸暂停（OSA）可能会增加患严重 COVID-19 的风险；然而，潜在调节程度尚未确定。本研究的目的是确定 OSA 高危、合并症与 COVID-19 风险增加、住院和重症监护病房（ICU）治疗之间的关系。
我们在 14 个国家/地区进行了一项横断面基于人群的网络调查，调查对象为成年人。该调查包括社会人口统计学变量和合并症。参与者被问及 COVID-19、住院和 ICU 治疗的问题。纳入了标准化问卷（STOP 问卷，用于评估 OSA 高危）。多变量逻辑回归用于调整各种因素。
在 26539 名受访者中，有 20598 名（35.4%为男性）完成了调查。参与者的平均年龄和 BMI 分别为 41.5±16.0 岁和 24.0±5.0kg/m2。医生诊断为 OSA 的患病率为 4.1%，高危 OSA 的患病率为 9.5%。我们发现，高危 OSA（调整后的优势比（aOR）1.72，95%置信区间（CI）：1.20，2.47）和糖尿病（aOR 2.07，95%CI：1.23，3.48）与 COVID-19 诊断报告相关。高危 OSA（aOR 2.11，95%CI：1.10-4.01）、男性（aOR：2.82，95%CI：1.55-5.12）、糖尿病（aOR：3.93，95%CI：1.70-9.12）和抑郁症（aOR：2.33，95%CI：1.15-4.77）与住院或 ICU 治疗风险增加相关。
高危 OSA 的参与者患 COVID-19 的几率增加，住院或 ICU 治疗的几率增加两倍。
