Cho Yongwon, Youn Seunghyun
AI Center, Korea University Anam Hospital, Seoul, Korea.
GRK Partners Research Center, Seoul, Korea.
Int Neurourol J. 2023 May;27(Suppl 1):S13-20. doi: 10.5213/inj.2346106.053. Epub 2023 May 31.
Our comprehension of interstitial cystitis/painful bladder syndrome (IC/PBS) has evolved over time. The term painful bladder syndrome, preferred by the International Continence Society, is characterized as "a syndrome marked by suprapubic pain during bladder filling, alongside increased daytime and nighttime frequency, in the absence of any proven urinary infection or other pathology." The diagnosis of IC/PBS primarily relies on symptoms of urgency/frequency and bladder/pelvic pain. The exact pathogenesis of IC/PBS remains a mystery, but it is postulated to be multifactorial. Theories range from bladder urothelial abnormalities, mast cell degranulation in the bladder, bladder inflammation, to altered bladder innervation. Therapeutic strategies encompass patient education, dietary and lifestyle modifications, medication, intravesical therapy, and surgical intervention. This article delves into the diagnosis, treatment, and prognosis prediction of IC/PBS, presenting the latest research findings, artificial intelligence technology applications in diagnosing major diseases in IC/PBS, and emerging treatment alternatives.
随着时间的推移,我们对间质性膀胱炎/疼痛性膀胱综合征(IC/PBS)的理解不断演变。国际尿控协会更倾向使用的术语“疼痛性膀胱综合征”,其特征为“一种在膀胱充盈期间耻骨上区疼痛,并伴有白天和夜间排尿频率增加,且不存在任何已证实的泌尿系统感染或其他病理状况的综合征”。IC/PBS的诊断主要依赖于尿急/尿频以及膀胱/盆腔疼痛的症状。IC/PBS的确切发病机制仍是一个谜,但据推测是多因素的。理论范围从膀胱尿路上皮异常、膀胱内肥大细胞脱颗粒、膀胱炎症到膀胱神经支配改变。治疗策略包括患者教育、饮食和生活方式调整、药物治疗、膀胱内治疗以及手术干预。本文深入探讨了IC/PBS的诊断、治疗和预后预测,介绍了最新的研究发现、人工智能技术在IC/PBS主要疾病诊断中的应用以及新兴的治疗选择。