Murakami Ryutaro, Mizuno Takeo
Zoological Institute, Faculty of Science, University of Tokyo, Tokyo 113, Japan.
Dev Growth Differ. 1984;26(5):419-426. doi: 10.1111/j.1440-169X.1984.00419.x.
The development of the os penis in normal male rats and the os clitoridis in the females treated with testosterone were studied histologically and histochemically. Alcian blue-positive materials, alkaline phosphatase activities and calcium deposit were detected. The os penis of the rats was composed of a proximal segment and a distal one. The proximal segment of the os penis was formed by the fusion of a membrane bone in its distal half and an ossifying hyaline cartilage in its proximal half. The distal segment of the os penis developed as a fibrocartilage bone. Two steps were demonstrated in the development of the os penis: the formation of the rudiments, and the differentiation of the proximal and distal segments. The treatment of newborn females with testosterone induced an os clitoridis homologous to the proximal segment of the os penis. The development of the os clitoridis was compared with that of the os penis.
对正常雄性大鼠阴茎骨的发育以及用睾酮处理的雌性大鼠阴蒂骨的发育进行了组织学和组织化学研究。检测到阿尔新蓝阳性物质、碱性磷酸酶活性和钙沉积。大鼠的阴茎骨由近端段和远端段组成。阴茎骨的近端段由其远端一半的膜性骨和近端一半的骨化透明软骨融合形成。阴茎骨的远端段发育为纤维软骨性骨。阴茎骨的发育表现为两个阶段：原基的形成以及近端和远端段的分化。用睾酮处理新生雌性大鼠可诱导出与阴茎骨近端段同源的阴蒂骨。将阴蒂骨的发育与阴茎骨的发育进行了比较。
