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雄激素及外生殖器与勃起组织相互作用信号的发育和功能作用。

Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues.

作者信息

Hashimoto Daiki, Fujimoto Kota, Nakata Masanori, Suzuki Takuya, Kumegawa Shinji, Ueda Yuko, Suzuki Kentaro, Asamura Shinichi, Yamada Gen

机构信息

Department of Physiology, Faculty of Medicine Wakayama Medical University Wakayama Japan.

Department of Urology Urological Science Institute, Yonsei University College of Medicine Seoul South Korea.

出版信息

Reprod Med Biol. 2024 Oct 6;23(1):e12611. doi: 10.1002/rmb2.12611. eCollection 2024 Jan-Dec.

DOI:10.1002/rmb2.12611
PMID:39372370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11456227/
Abstract

BACKGROUND

Recent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis. Accumulated data showed their fundamental functions also for erectile tissue (corporal body) development and its abnormalities. The current review focuses on such signals from developmental and functional viewpoints.

METHODS

Experimental strategies including histological and molecular signal analyses with conditional mutant mice for androgen and Wnt signals have been extensively utilized.

MAIN FINDINGS

Essential roles of androgen for the development of male-type ExG and urethral formation are shown. Wnt signals are associated with androgen for male-type ExG organogenesis. Androgen plays essential roles in the development of erectile tissue, the corporal body and it also regulates the duration time of erection. Wnt and other signals are essential for the regulation of mesenchymal cells of erectile tissue as shown by its conditional mutant mouse analyses. Stress signals, continuous erection, and the potential of lymphatic characteristics of the erectile vessels with sinusoids are also shown.

CONCLUSION

Reiterated involvement of androgen, Wnt, and other regulatory factors is stated for the development and pathogenesis of ExG and erectile tissues.

摘要

背景

分子和信号分析方面的最新进展揭示了细胞信号的重要功能，包括雄激素以及外生殖器（ExG）发育及其发病机制中相关生长因子，如Wnt调节因子。积累的数据表明，它们在勃起组织（海绵体）发育及其异常方面也具有基本功能。本综述从发育和功能角度关注此类信号。

方法

广泛采用了包括对雄激素和Wnt信号的条件性突变小鼠进行组织学和分子信号分析等实验策略。

主要发现

显示了雄激素在男性型外生殖器发育和尿道形成中的重要作用。Wnt信号与雄激素在男性型外生殖器器官发生过程中相关联。雄激素在勃起组织、海绵体的发育中起重要作用，并且还调节勃起持续时间。对条件性突变小鼠的分析表明，Wnt和其他信号对于勃起组织间充质细胞的调节至关重要。还展示了应激信号、持续性勃起以及具有窦状隙的勃起血管的淋巴特性潜力。

结论

重申了雄激素、Wnt和其他调节因子在ExG和勃起组织的发育及发病机制中的参与情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/6ccec5a8b43b/RMB2-23-e12611-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/79cbc74b82de/RMB2-23-e12611-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/2cd1387b2957/RMB2-23-e12611-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/d1807e81a5e4/RMB2-23-e12611-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/9a33e19af6b5/RMB2-23-e12611-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/6ccec5a8b43b/RMB2-23-e12611-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/79cbc74b82de/RMB2-23-e12611-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/2cd1387b2957/RMB2-23-e12611-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/d1807e81a5e4/RMB2-23-e12611-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/9a33e19af6b5/RMB2-23-e12611-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17e/11456227/6ccec5a8b43b/RMB2-23-e12611-g001.jpg

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本文引用的文献

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2
Clinical Presentation of Peyronie's Disease: A Retrospective Study of 564 Cases.佩罗尼氏病的临床表现：564例回顾性研究
Diagnostics (Basel). 2024 May 29;14(11):1125. doi: 10.3390/diagnostics14111125.
3
Single-cell transcriptome analysis of cavernous tissues reveals the key roles of pericytes in diabetic erectile dysfunction.单细胞转录组分析海绵体组织揭示周细胞在糖尿病性勃起功能障碍中的关键作用。
Elife. 2024 Jun 10;12:RP88942. doi: 10.7554/eLife.88942.
4
Novel erectile analyses revealed augmentable penile Lyve-1, the lymphatic marker, expression.新型勃起分析显示，阴茎中淋巴管标志物Lyve-1的表达可增强。
Reprod Med Biol. 2024 Apr 1;23(1):e12570. doi: 10.1002/rmb2.12570. eCollection 2024 Jan-Dec.
5
Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape.Tgfbr1 通过重塑其调控景观来控制后肢和外部生殖器之间的发育可塑性。
Nat Commun. 2024 Mar 20;15(1):2509. doi: 10.1038/s41467-024-46870-z.
6
Corpora cavernosa fibroblasts mediate penile erection.海绵体纤维细胞介导阴茎勃起。
Science. 2024 Feb 9;383(6683):eade8064. doi: 10.1126/science.ade8064.
7
Penile cavernous sinusoids are Prox1-positive hybrid vessels.阴茎海绵体血窦是Prox1阳性的混合血管。
Vasc Biol. 2024 Jan 11;6(1). doi: 10.1530/VB-23-0014. Print 2024 Jan 1.
8
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Biology (Basel). 2023 Nov 16;12(11):1441. doi: 10.3390/biology12111441.
9
Stem cell therapy for erectile dysfunction: a systematic review.干细胞治疗勃起功能障碍：系统评价。
Sex Med Rev. 2023 Dec 23;12(1):87-93. doi: 10.1093/sxmrev/qead040.
10
Histogenesis of the Os Penis and Os Clitoridis in Rats: (chondrogenesis/bone formation/testosterone/genital tubercle).大鼠阴茎骨和阴蒂骨的组织发生：（软骨形成/骨形成/睾酮/生殖结节）
Dev Growth Differ. 1984;26(5):419-426. doi: 10.1111/j.1440-169X.1984.00419.x.