Lutz J
Am J Clin Nutr. 1986 Jul;44(1):99-106. doi: 10.1093/ajcn/44.1.99.
Data on factors potentially responsible for familial differences in the incidence of postmenopausal osteoporosis were obtained for 26 mother/daughter pairs. The factors were: bone mineral content of the radius (BMC); bone mineral content to bone width ratio (BMC/W); serum ionized (Ca++), ultrafiltrable (UF-Ca) and total calcium (T-Ca), ultrafiltrable and total magnesium, and 25-hydroxyvitamin D; and 7-day dietary intakes of selected nutrients. The BMC, BMC/W, and serum calcium fractions of the mothers were significantly correlated with those of the daughters. Although the BMC of the mothers was related to their caloric intakes, the interrelations between BMC and other variables of each group were not significant. Estimates of heritability, a measure of familial resemblance, were 0.724 for BMC; 0.570 for BMC/W; and 0.932, 0.916, and 0.668 for Ca++, UF-Ca, and T-Ca, respectively. Mothers with low BMC tended to have daughters with low BMC; there were also familial resemblances in serum calcium fractions.
我们获取了26对母女的数据，这些数据涉及可能导致绝经后骨质疏松症发病率存在家族差异的因素。这些因素包括：桡骨骨矿物质含量（BMC）；骨矿物质含量与骨宽度之比（BMC/W）；血清离子钙（Ca++）、可超滤钙（UF-Ca）和总钙（T-Ca）、可超滤镁和总镁，以及25-羟基维生素D；还有特定营养素的7天膳食摄入量。母亲的BMC、BMC/W和血清钙组分与女儿的这些指标显著相关。虽然母亲的BMC与她们的热量摄入有关，但每组中BMC与其他变量之间的相互关系并不显著。遗传度（衡量家族相似性的指标）的估计值为：BMC为0.724；BMC/W为0.570；Ca++、UF-Ca和T-Ca分别为0.932、0.916和0.668。BMC低的母亲往往有BMC低的女儿；血清钙组分也存在家族相似性。
