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用蜂王浆衍生的细胞外囊泡形成支架用于伤口愈合。

formed scaffold with royal jelly-derived extracellular vesicles for wound healing.

机构信息

The Research and Application Center of Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.

Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518132, China.

出版信息

Theranostics. 2023 May 8;13(9):2811-2824. doi: 10.7150/thno.84665. eCollection 2023.

DOI:10.7150/thno.84665
PMID:37284440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10240823/
Abstract

Safe and effective wound healing can be a major clinical challenge. Inflammation and vascular impairment are two main causes of inadequate wound healing. Here, we developed a versatile hydrogel wound dressing, comprising a straightforward physical mixture of royal jelly-derived extracellular vesicles (RJ-EVs) and methacrylic anhydride modified sericin (SerMA), to accelerate wound healing by inhibiting inflammation and promoting vascular reparation. The RJ-EVs showed satisfactory anti-inflammatory and antioxidant effects, and significantly promoted L929 cell proliferation and migration . Meanwhile, the photocrosslinked SerMA hydrogel with its porous interior structure and high fluidity made it a good candidate for wound dressing. The RJ-EVs can be gradually released from the SerMA hydrogel at the wound site, ensuring the restorative effect of RJ-EVs. In a full-thickness skin defect model, the SerMA/RJ-EVs hydrogel dressing accelerated wound healing with a healing rate of 96.8% by improving cell proliferation and angiogenesis. The RNA sequencing results further revealed that the SerMA/RJ-EVs hydrogel dressing was involved in inflammatory damage repair-related pathways including recombinational repair, epidermis development, and Wnt signaling. This SerMA/RJ-EVs hydrogel dressing offers a simple, safe and robust strategy for modulating inflammation and vascular impairment for accelerated wound healing.

摘要

安全有效的伤口愈合可能是一个重大的临床挑战。炎症和血管损伤是导致伤口愈合不良的两个主要原因。在这里，我们开发了一种多功能水凝胶伤口敷料，由蜂王浆衍生的细胞外囊泡（RJ-EVs）和甲基丙烯酰化丝胶（SerMA）的简单物理混合物组成，通过抑制炎症和促进血管修复来加速伤口愈合。RJ-EVs 表现出令人满意的抗炎和抗氧化作用，并显著促进了 L929 细胞的增殖和迁移。同时，具有多孔内部结构和高流动性的光交联 SerMA 水凝胶使其成为伤口敷料的良好候选物。RJ-EVs 可以从伤口部位的 SerMA 水凝胶中逐渐释放出来，确保 RJ-EVs 的修复效果。在全厚皮缺损模型中，SerMA/RJ-EVs 水凝胶敷料通过改善细胞增殖和血管生成，以 96.8%的愈合率加速伤口愈合。RNA 测序结果进一步表明，SerMA/RJ-EVs 水凝胶敷料参与了与炎症损伤修复相关的途径，包括重组修复、表皮发育和 Wnt 信号通路。这种 SerMA/RJ-EVs 水凝胶敷料为调节炎症和血管损伤以加速伤口愈合提供了一种简单、安全和强大的策略。

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