Guan Gaopeng, Zhang Qin, Jiang Zhenzhen, Liu Jie, Wan Jinjing, Jin Ping, Lv Qizhuang
Department of Endocrinology, Third Xiangya Hospital of Central South University, Hunan Province, Changsha, 410013, China.
Department of Cardiology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, 332000, China.
Small. 2022 Dec;18(51):e2203064. doi: 10.1002/smll.202203064. Epub 2022 Nov 4.
Diabetic wound is one of the common complications in diabetic patients, which exhibits chronic, hard-to-heal characteristics. The healing process of wounds is impaired by several factors, including excessive oxidative stress, blocked angiogenesis, and bacterial infection. The therapeutic effects of traditional microneedle patches remain not satisfactory, due to their difficulty simultaneously targeting multiple targets to treat diabetic wounds. As such, there is an urgent need to develop a multifunctional microneedle (MN) patch for promoting the healing of diabetic wounds. A multifunctional MN patch with antioxidant, proangiogenesis, and antibacterial capacities was fabricated to target the pathogenesis of diabetic wounds. Silk fibroin methacryloyl, which has excellent biocompatibility, stable mechanical properties, and well processability, and is selected as the base material for multifunctional MN patches. Prussian blue nanozymes (PBNs) and vascular endothelial growth factor (VEGF) are encapsulated in tips of MN patches, Polymyxin is encapsulated in base layers of MN patches. Based on synergic properties of these components, multifunctional MN patches exhibit excellent biocompatibility, drug-sustained release, proangiogenesis, antioxidant, and antibacterial properties. The developed multifunctional MN patches accelerate diabetic wound healing, providing a potential therapeutic approach.
糖尿病伤口是糖尿病患者常见的并发症之一，具有慢性、难愈合的特点。伤口愈合过程受到多种因素的损害，包括过度的氧化应激、血管生成受阻和细菌感染。传统微针贴片的治疗效果仍不尽人意，因为它们难以同时针对多个靶点来治疗糖尿病伤口。因此，迫切需要开发一种多功能微针（MN）贴片来促进糖尿病伤口的愈合。制备了一种具有抗氧化、促血管生成和抗菌能力的多功能MN贴片，以针对糖尿病伤口的发病机制。甲基丙烯酰化丝素蛋白具有优异的生物相容性、稳定的机械性能和良好的加工性能，被选为多功能MN贴片的基材。普鲁士蓝纳米酶（PBNs）和血管内皮生长因子（VEGF）被包裹在MN贴片的尖端，多粘菌素被包裹在MN贴片的基层。基于这些成分的协同特性，多功能MN贴片具有优异的生物相容性、药物缓释、促血管生成、抗氧化和抗菌性能。所开发的多功能MN贴片加速了糖尿病伤口的愈合，提供了一种潜在的治疗方法。
