Hosoya Masahiro, Saito Yusuke, Horiuchi Yousuke
API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-Chome, Toyonaka, Osaka 561-0825, Japan.
Carbon Neutral Promotion Division, ARK Creation Centre, Cataler Corporation, 1905-10 Shimonobe, Iwata, Shizuoka 438-0112, Japan.
Beilstein J Org Chem. 2023 May 31;19:752-763. doi: 10.3762/bjoc.19.55. eCollection 2023.
We report on the high potential of a honeycomb reactor for the use in aerobic oxidation under continuous-flow conditions. The honeycomb reactor is made of porous material with narrow channels separated by porous walls allowing for high density accumulation in the reactor. This structure raised the mixing efficiency of a gas-liquid reaction system, and it effectively accelerated the aerobic oxidation of benzyl alcohols to benzaldehydes under continuous-flow conditions. This reactor is a promising device for streamlining aerobic oxidation with high process safety because it is a closed system.
我们报道了一种蜂窝反应器在连续流动条件下用于需氧氧化的巨大潜力。该蜂窝反应器由多孔材料制成,其狭窄通道被多孔壁隔开,可在反应器中实现高密度堆积。这种结构提高了气液反应体系的混合效率,并在连续流动条件下有效地加速了苯甲醇向苯甲醛的需氧氧化。该反应器是一种很有前景的装置,可用于简化需氧氧化过程并具有高过程安全性,因为它是一个封闭系统。