Bradley Ray is with RTI International, Research Triangle Park, NC. Steven J. Korzeniewski is with the School of Medicine, Wayne State University, Detroit, MI. George Mohler is with the Computer Science Department, Boston College, Chestnut Hill, MA. Jennifer J. Carroll is with the Department of Sociology and Anthropology, North Carolina State University, Raleigh. Brandon del Pozo is with the Warren Alpert School of Medicine, Brown University, Providence, RI. Grant Victor is with the School of Social Work, Rutgers University, New Brunswick, NJ. Philip Huynh and Bethany J. Hedden are with the Center for Behavioral Health and Justice, Wayne State University.
Am J Public Health. 2023 Jul;113(7):750-758. doi: 10.2105/AJPH.2023.307291.
To test the hypothesis that law enforcement efforts to disrupt local drug markets by seizing opioids or stimulants are associated with increased spatiotemporal clustering of overdose events in the surrounding geographic area. We performed a retrospective (January 1, 2020 to December 31, 2021), population-based cohort study using administrative data from Marion County, Indiana. We compared frequency and characteristics of drug (i.e., opioids and stimulants) seizures with changes in fatal overdose, emergency medical services nonfatal overdose calls for service, and naloxone administration in the geographic area and time following the seizures. Within 7, 14, and 21 days, opioid-related law enforcement drug seizures were significantly associated with increased spatiotemporal clustering of overdoses within radii of 100, 250, and 500 meters. For example, the observed number of fatal overdoses was two-fold higher than expected under the null distribution within 7 days and 500 meters following opioid-related seizures. To a lesser extent, stimulant-related drug seizures were associated with increased spatiotemporal clustering overdose. Supply-side enforcement interventions and drug policies should be further explored to determine whether they exacerbate an ongoing overdose epidemic and negatively affect the nation's life expectancy. (. 2023;113(7):750-758. https://doi.org/10.2105/AJPH.2023.307291).
为了验证以下假设，即执法部门通过没收阿片类药物或兴奋剂来扰乱当地毒品市场的努力与周边地理区域内过量用药事件的时空聚集增加有关。我们使用印第安纳州马里恩县的行政数据进行了一项回顾性（2020 年 1 月 1 日至 2021 年 12 月 31 日）、基于人群的队列研究。我们比较了在药物（即阿片类药物和兴奋剂）缉获前后，在地理区域和时间内，致命性过量用药、紧急医疗服务非致命性过量用药呼叫服务和纳洛酮给药的频率和特征的变化。在 7、14 和 21 天内，与阿片类药物相关的执法缉毒行动与半径为 100、250 和 500 米内的过量用药的时空聚集增加显著相关。例如，在与阿片类药物相关的缉毒行动后 7 天和 500 米范围内，观察到的致命性过量用药数量是在零假设分布下的两倍。在较小程度上，与兴奋剂相关的缉毒行动与时空聚集的过量用药增加有关。应进一步探索供应方执法干预措施和毒品政策，以确定它们是否会加剧正在进行的过量用药流行并对国家预期寿命产生负面影响。（2023；113(7):750-758. https://doi.org/10.2105/AJPH.2023.307291）。
