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具有分层结构涂层的仿生医学留置导管,具有特定的润湿性和抗菌性能。

Bioinspired medical indwelling catheters with hierarchically structured coatings exhibiting specific wettability and antibacterial property.

机构信息

Children's Medical Center, Taihe Hospital, Hubei University of Medicine, Hubei, China.

Department of Hematology, Taihe Hospital, Hubei University of Medicine, Hubei, China.

出版信息

Colloids Surf B Biointerfaces. 2023 Jul;227:113388. doi: 10.1016/j.colsurfb.2023.113388. Epub 2023 Jun 1.

DOI:10.1016/j.colsurfb.2023.113388
PMID:37285668
Abstract

The use of medical indwelling catheters in conjunction with implantable medical devices has saved countless lives in various medical procedures. However, biofilm formation on catheter surfaces remains a persistent problem that can lead to chronic infections and device failure. Current approaches to addressing this issue involve the use of biocidal agents or self-cleaning surfaces, but these methods are limited in their effectiveness. Superwettable surfaces have shown great promise in preventing biofilm formation by manipulating the adhesive properties between bacteria and catheter surfaces. In this study, we present a novel medical indwelling catheter with hierarchically structured coatings that exhibit specific wettability and antibacterial properties. By integrating the hierarchical structure and specific wettability, we have developed an indwelling catheter with high flexibility and self-cleaning ability, which is very promising in biomedical engineering applications. Our approach draws inspiration from natural examples, such as the compound eyes of mosquitoes and lotus leaves, and represents a significant step forward in the development of effective anti-infection strategies for medical indwelling catheters.

摘要

在各种医疗程序中,医用留置导管与植入式医疗器械联合使用挽救了无数生命。然而,导管表面生物膜的形成仍然是一个持续存在的问题,可能导致慢性感染和器械故障。目前解决这个问题的方法涉及使用杀菌剂或自清洁表面,但这些方法在效果上存在局限性。超润湿表面通过操纵细菌和导管表面之间的粘附特性,在防止生物膜形成方面显示出巨大的潜力。在这项研究中,我们提出了一种具有分层结构涂层的新型医用留置导管,该导管具有特定的润湿性和抗菌性能。通过整合分层结构和特定的润湿性,我们开发出了一种具有高柔韧性和自清洁能力的留置导管,在生物医学工程应用中具有很大的应用前景。我们的方法从蚊子的复眼和荷叶等自然实例中获得灵感,代表了在开发用于医用留置导管的有效抗感染策略方面的重要进展。

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Colloids Surf B Biointerfaces. 2023 Jul;227:113388. doi: 10.1016/j.colsurfb.2023.113388. Epub 2023 Jun 1.
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