Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
作者信息
Yin Han, Inoue Asuka, Ma Zhengxiong, Zhu Xinyan, Xia Ruixue, Xu Zhenmei, Wang Na, Duan Yaning, Zhang Anqi, Guo Changyou, He Yuanzheng
机构信息
Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, Japan.
出版信息
Cell Res. 2023 Aug;33(8):644-647. doi: 10.1038/s41422-023-00835-x. Epub 2023 Jun 7.
Abstract
摘要
相似文献
1
Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity.
Cell Res. 2023 Aug;33(8):644-647. doi: 10.1038/s41422-023-00835-x. Epub 2023 Jun 7.
2
Free fatty acid receptor 4-β-arrestin 2 pathway mediates the effects of different classes of unsaturated fatty acids in osteoclasts and osteoblasts.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):281-289. doi: 10.1016/j.bbalip.2018.12.009. Epub 2018 Dec 19.
3
Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.
J Nutr Biochem. 2023 Feb;112:109222. doi: 10.1016/j.jnutbio.2022.109222. Epub 2022 Nov 17.
4
In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.
J Lipid Res. 2017 Jan;58(1):236-246. doi: 10.1194/jlr.M072769. Epub 2016 Nov 3.
5
Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice.
J Am Heart Assoc. 2015 Apr 6;4(4):e001856. doi: 10.1161/JAHA.115.001856.
6
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
Cell. 2019 Nov 27;179(6):1289-1305.e21. doi: 10.1016/j.cell.2019.11.005. Epub 2019 Nov 21.
7
Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon.
Inflamm Res. 2015 Oct;64(10):809-815. doi: 10.1007/s00011-015-0864-3. Epub 2015 Aug 15.
8
Endogenous -3 PUFAs Improve Non-Alcoholic Fatty Liver Disease through FFAR4-Mediated Gut-Liver Crosstalk.
Nutrients. 2023 Jan 22;15(3):586. doi: 10.3390/nu15030586.
9
FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids.
Mediators Inflamm. 2016;2016:1536047. doi: 10.1155/2016/1536047. Epub 2016 Nov 24.
10
Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta.
Placenta. 2014 Jul;35(7):523-5. doi: 10.1016/j.placenta.2014.04.017. Epub 2014 May 9.
引用本文的文献
1
Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6.
Proc Natl Acad Sci U S A. 2025 Jan 28;122(4):e2415426122. doi: 10.1073/pnas.2415426122. Epub 2025 Jan 23.
2
Exploring the constitutive activation mechanism of the class A orphan GPR20.
Acta Pharmacol Sin. 2025 Feb;46(2):500-511. doi: 10.1038/s41401-024-01385-7. Epub 2024 Sep 10.
3
Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor.
Sci Adv. 2024 Aug 16;10(33):eadn7771. doi: 10.1126/sciadv.adn7771.
4
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor.
Cell. 2024 Aug 22;187(17):4751-4769.e25. doi: 10.1016/j.cell.2024.07.005. Epub 2024 Jul 31.
5
Hematopoietic heterogeneity starts at the hemogenic endothelium.
Cell Res. 2023 Jun;33(6):413-414. doi: 10.1038/s41422-023-00806-2.
6
Repurposing FBP1: dephosphorylating IκBα to suppress NFκB.
Cell Res. 2023 Jun;33(6):419-420. doi: 10.1038/s41422-023-00785-4.
本文引用的文献
1
Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science. 2023 Apr 7;380(6640):eadd6220. doi: 10.1126/science.add6220.
2
The role of G protein conformation in receptor-G protein selectivity.
Nat Chem Biol. 2023 Jun;19(6):687-694. doi: 10.1038/s41589-022-01231-z. Epub 2023 Jan 16.
3
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.
Nat Struct Mol Biol. 2022 Sep;29(9):863-870. doi: 10.1038/s41594-022-00816-5. Epub 2022 Aug 15.
4
Structural basis of leukotriene B4 receptor 1 activation.
Nat Commun. 2022 Mar 3;13(1):1156. doi: 10.1038/s41467-022-28820-9.
5
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun. 2022 Feb 8;13(1):731. doi: 10.1038/s41467-022-28417-2.
6
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
Nat Chem Biol. 2022 Mar;18(3):281-288. doi: 10.1038/s41589-021-00930-3. Epub 2021 Dec 22.
7
Cryo-EM structure of the human histamine H receptor/G complex.
Nat Commun. 2021 Apr 7;12(1):2086. doi: 10.1038/s41467-021-22427-2.
8
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E receptor EP2 subtype.
Sci Adv. 2021 Apr 2;7(14). doi: 10.1126/sciadv.abf1268. Print 2021 Apr.
9
Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators.
Int J Mol Sci. 2021 Feb 10;22(4):1763. doi: 10.3390/ijms22041763.
10
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein.
Structure. 2021 Mar 4;29(3):252-260.e6. doi: 10.1016/j.str.2020.11.007. Epub 2020 Dec 1.
Zotero 插件