表没食子儿茶素没食子酸酯介导的羟基磷灰石的合成与表征
Synthesis and Characterization of Epigallocatechin Gallate-mediated Hydroxyapatite.
作者信息
Dinesh Hanish, Sundar Sandhya, Kannan Saranya, Ramadoss Ramya, Selvam Suganya Panneer, Ramani Pratibha
机构信息
Department of Oral Pathology & Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India.
Functional Nanomaterials Laboratory (Green Lab), Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, Chennai, 600077, India.
出版信息
Pharm Nanotechnol. 2024;12(2):165-170. doi: 10.2174/2211738511666230607113610.
INTRODUCTION
Hydroxyapatite is a significant material that finds its application in the field of dental and bone tissue engineering.
METHODS
The formulation of nanohydroxyapatite with the aid of bioactive compounds has gained importance in recent years due to the beneficial activity contributed by them. The present work focuses on the formulation of nanohydroxyapatite synthesis using epigallocatechin gallate, an active biochemical component of green tea.
RESULTS
The prepared epigallocatechin gallate-mediated nanohydroxyapatite (epi-HAp) was nanoglobular in shape and composed of calcium, phosphorous, carbon and oxygen, which was confirmed by Scanning electron microscope- energy dispersive X-ray analysis (SEM-EDX). The Attenuated Total Reflection- Infra red spectroscopy (ATR-IR) and X-ray photoelectron spectroscopy (XPS) assured that the reduction and stabilisation of nanohydroxyapatite were mediated by epigallocatechin gallate.
CONCLUSION
The epi-HAp exhibited anti-inflammatory behaviour along with nil effect on cytotoxicity. To be precise, the epi-HAp can be an effective biomaterial in bone and dental applications.
引言
羟基磷灰石是一种重要材料，在牙科和骨组织工程领域有应用。
方法
近年来，借助生物活性化合物制备纳米羟基磷灰石因其所具有的有益活性而变得重要。目前的工作重点是使用表没食子儿茶素 gallate（绿茶的一种活性生化成分）来合成纳米羟基磷灰石。
结果
所制备的表没食子儿茶素 gallate 介导的纳米羟基磷灰石（epi-HAp）呈纳米球状，由钙、磷、碳和氧组成，这通过扫描电子显微镜 - 能量色散X射线分析（SEM-EDX）得以证实。衰减全反射 - 红外光谱（ATR-IR）和X射线光电子能谱（XPS）表明纳米羟基磷灰石的还原和稳定是由表没食子儿茶素 gallate 介导的。
结论
epi-HAp 表现出抗炎行为且对细胞毒性无影响。确切地说，epi-HAp 在骨和牙科应用中可以是一种有效的生物材料。
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